| 门冬氨酸钾镁对冠状动脉造影术后患者钾离子水平及QTc间期的影响 |
| |
| 引用本文： | 刘玥,马振华,魏丽萍,齐新,安亚娟. 门冬氨酸钾镁对冠状动脉造影术后患者钾离子水平及QTc间期的影响[J]. 心脏杂志, 2022, 34(6): 645-648+653. DOI: 10.12125/j.chj.202201088 |
| |
| 作者姓名： | 刘玥 马振华 魏丽萍 齐新 安亚娟 |
| |
| 作者单位： | 1.天津市人民医院心内科 天津 300121 |
| |
| 基金项目： | 天津市人民医院课题资助（2019YJ016）；天津市中医药管理局课题资助（2021155） |
| |
| 摘 要： | 目的 探讨术前应用门冬氨酸钾镁对冠状动脉造影患者术后血清钾离子水平以及QTc间期的影响。方法 入选2019年1月～2020年11月于天津市人民医院心内科住院行冠状动脉造影检查的患者共282例，分为门冬氨酸钾镁组（n=138）与氯化钾组（n=144）。门冬氨酸钾镁治疗组患者术前应用门冬氨酸钾镁30 ml静脉输液治疗，常规氯化钾组患者术前应用氯化钾0.5 g静脉输液治疗。记录两组患者术前及术后血清钾离子、钠离子、氯离子、血清肌酐、红细胞、血红蛋白、红细胞压积和QTc间期等指标，并比较手术前后各项指标的变化。计算两组患者Gensini评分，评估患者发生QTc间期与冠脉病变及电解质的相关性。结果 在门冬氨酸钾镁治疗组，血清钾离子、血红蛋白、红细胞计数、血小板计数及红细胞压积均较术前降低（均P<0.01），而血清钠离子、氯离子、血清肌酐以及QTc间期较术前升高（均P<0.01）；血小板容积与术前比较差异无统计学意义。在氯化钾组，血清钾离子、血红蛋白、红细胞计数、红细胞压积、血小板均较术前降低（均P<0.01），血清钠离子、氯离子及QTc间期较术前有所升高（均P<0.01）...
|
| 关 键 词： | 门冬氨酸钾镁 冠状动脉造影术 低钾血症 QTc间期 |
| 收稿时间： | 2022-01-21 |
Effects of potassium-magnesium aspartate on potassium levels and QTc interval of patients after coronary angiography |
| |
| Affiliation: | 1.Department of Cardiology, People’s Hospital of Tianjin, Tianjin 300121, China2.Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China |
| |
| Abstract: | AIM To evaluate the effect of potassium-magnesium aspartate on serum potassium levels and QTc interval in patients after coronary angiography. METHODS The study subjects were from the cardiovascular department of Tianjin People’s Hospital from January 2019 to November 2020.282 patients with coronary angiography were selected and divided into the magnesium-potassium aspartate group (138 cases) and the potassium chloride group (144 cases).The magnesium-potassium aspartate group was treated with 30ml magnesium-potassium aspartate and the potassium chloride group with 0.5g potassium chloride before operation. Such changes of index were observed as serum potassium, sodium, chloride, serum creatinine, red blood cells, hemoglobin, red blood cell hematocrit, QTc (QT interval corrected) . Gensini scores were calculated in order to evaluate the extent of QTc prolongation in patients after coronary angiography, its relationship to coronary lesions and electrolytes. RESULTS In the potassium magnesium aspartate treatment group, serum potassium ion, hemoglobin, erythrocyte count, platelet count and hematocrit were lower than those before operation (all P<0.01), while serum sodium ion, chloride ion, serum creatinine and QTc interval were higher than those before operation (all P<0.01); There was no significant difference in platelet volume between before and after operation. In potassium chloride group, serum potassium ion, hemoglobin, erythrocyte count, hematocrit and platelet were lower than those before operation (all P<0.01), serum sodium ion, chloride ion and QTc interval were higher than those before operation (all P<0.01), and there was no significant difference in serum creatinine and platelet volume; Compared with the potassium chloride group in the same period, the proportion of hypokalemia (P<0.05) and QTc in the potassium magnesium aspartate treatment group were lower than those before operation (P<0.01). Binary Logistic regression analysis showed that preoperative application of potassium magnesium aspartate was an independent protective factor for hypokalemia (P<0.01), and postoperative potassium ion level was an influencing factor for the prolongation of QTc compared with that before operation (P<0.05). QTc in postoperative patients was longer than that before operation, which was significantly negatively correlated with postoperative blood potassium level, negatively correlated with postoperative erythrocyte level (all P<0.05), and positively correlated with age (P<0.05). CONCLUSION Treatment of magnesium-potassium aspartate can significantly decrease the incidence of hypokalemia,QTc prolongation and arrhythmias in patients after coronary angiography. |
| |
| Keywords: | |
|
| 点击此处可从《心脏杂志》浏览原始摘要信息 |
|
点击此处可从《心脏杂志》下载免费的PDF全文 |
|
