| 舌下含服尘螨滴剂联合盐酸西替利嗪滴剂、氮卓斯汀喷鼻在小儿变应性鼻炎中的治疗效果 |
| |
| 引用本文： | 秦欠欠 廉用成. 舌下含服尘螨滴剂联合盐酸西替利嗪滴剂、氮卓斯汀喷鼻在小儿变应性鼻炎中的治疗效果[J]. 国际医药卫生导报, 2022, 28(23): 3300. DOI: 10.3760/cma.j.issn.1007-1245.2022.23.011 |
| |
| 作者姓名： | 秦欠欠 廉用成 |
| |
| 作者单位： | 焦作市妇幼保健院耳鼻咽喉科，焦作 454000 |
| |
| 摘 要： | 目的 探讨尘螨滴剂联合西替利嗪、氮卓斯汀治疗小儿变应性鼻炎（AR）的临床价值。方法 选取2020年6月至2022年3月焦作市妇幼保健院160例AR患儿，根据治疗方案差异分为对照组（80例，接受西替利嗪治疗）和研究组（80例，接受西替利嗪联合舌下含服尘螨滴剂治疗），疗程均为2个月。对比两组症状改善时间，治疗前后的C反应蛋白（CRP）、免疫球蛋白A、E、M（IgA、IgE、IgM）、白细胞介素6（IL-6）水平及不良反应。统计学方法采用t检验、χ2检验。结果 治疗后患儿症状改善情况：研究组患儿鼻塞、流涕、鼻痒、喷嚏改善时间均短于对照组（t=9.792、5.810、5.737、4.969，均P<0.05）；两组治疗前后免疫因子对比：治疗前两组IgM、IgA、IgE，差异均无统计学意义（t=0.714、0.529、0.474，均P>0.05），治疗后研究组IgM、IgA、IgE水平均低于对照组，差异均有统计学意义（t=2.879、5.464、0.584，均P<0.05）；治疗前研究组与对照组CRP［（8.13±0.95）mg/L比（8.03±0.89）mg/L］、IL-6［（36.47±10.97）pg/ml比（30.52±6.23）pg/ml］对比，差异均无统计学意义（t=0.518、0.026，均P>0.05），治疗后研究组的CRP、IL-6均低于对照组，差异均有统计学意义（t=13.871、4.912，均P<0.05）；两组总不良反应率对比：对照组总不良反应率为11.25%（9/80），研究组总不良反应率为10.00%（8/80），差异无统计学意义（χ2=0.066，P=0.798）。结论 尘螨滴剂联合盐酸西替利嗪、氮卓斯汀治疗可有效缩短AR患儿症状改善时间，改善患儿血清炎性因子及免疫因子水平。
|
| 关 键 词： | 过敏性鼻炎 儿童 尘螨滴剂 西替利嗪 氮卓斯汀 免疫功能 |
| 收稿时间： | 2022-09-06 |
Sublingual dust mite drops combined with cetirizine hydrochloride dropsand azelastine nasal spray in treatment of children with allergic rhinitis |
| |
| Qin Qianqian,Lian Yongcheng. Sublingual dust mite drops combined with cetirizine hydrochloride dropsand azelastine nasal spray in treatment of children with allergic rhinitis[J]. International Medicine & Health Guidance News, 2022, 28(23): 3300. DOI: 10.3760/cma.j.issn.1007-1245.2022.23.011 |
| |
| Authors: | Qin Qianqian Lian Yongcheng |
| |
| Affiliation: | Department of Otolaryngology, Jiaozuo Maternal and Child HealthHospital, Jiaozuo 454000, China |
| |
| Abstract: | Objective To investigate the clinical value of dust mite drops combined withcetirizine and azelastine in the treatment of children with allergic rhinitis(AR). Methods One hundred and sixtychildren with AR treated at Jiaozuo Maternal and Child Health Hospital fromJune 2020 to March 2022 were selected. According to the treatment schemes, theywere divided into a control group, treated by cetirizine, and a study group, treatedby cetirizine and sublingual dust mite drops, with 80 cases in each group. Bothgroups were treated for 2 months. The symptom improvement times, the levels ofC-reactive protein (CRP), immunoglobulin A, E, and M (IgA, IgE, and IgM), andinterleukin-6 (IL-6) before and after the treatment, and adverse reactions werecompared between the two groups.t and χ2 tests were applied. Results The improvement times of nasal congestion ,runny nose , nasal itching , and sneezing in the study group were shorter than those in the control group (t=9.792, 5.810, 5.737, and 4.969;all P<0.05). Before the treatment, therewere no statistical differences in IgM , IgA , and IgE between the two groups (t=0.714, 0.529, and 0.474; all P>0.05).After the treatment, the levels of IgM , IgA , and IgE in the study group were lower than those inthe control group, with statistical differences (t=2.879, 5.464, and 0.584;all P<0.05).Before the treatment, there no statistical differences in CRP [(8.13±0.95)mg/Lvs. (8.03±0.89)mg/L] and IL-6 [(36.47±10.97) pg/ml vs. (30.52±6.23)pg/ml]between the study group and the control group, with no statistical differences(t=0.518 and 0.026; both P<0.05). After the treatment, thelevels of CRP and IL-6 in the studygroup were lower than those in the control group, with significant differences(t=13.871 and 4.912; both P<0.05). The total incidence ofadverse reactions was 11.25%(9/80) in the control group, and was 10.00%(8/80)in the study group, with no statistical difference （χ2=0.066， P=0.798). Conclusion Dust mite drops combined with cetirizine hydrochloride and azelastinecan effectively shorten the time of symptom improvement in children with AR,and improve the levels of serum inflammatory factors and immune factors. |
| |
| Keywords: | Allergic rhinitis Children Dust mite drops Cetirizine Azelastine Immune function |
|
| 点击此处可从《国际医药卫生导报》浏览原始摘要信息 |
|
点击此处可从《国际医药卫生导报》下载免费的PDF全文 |
|
