| 儿童肺炎克雷伯菌感染临床行为研究 |
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| 引用本文： | 史贵秀 陈海英 费秀昆 曾庆贺 郁真真. 儿童肺炎克雷伯菌感染临床行为研究[J]. 国际医药卫生导报, 2022, 28(16): 2299-2302. DOI: 10.3760/cma.j.issn.1007-1245.2022.16.019 |
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| 作者姓名： | 史贵秀 陈海英 费秀昆 曾庆贺 郁真真 |
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| 作者单位： | 1枣庄市妇幼保健院感染科，枣庄 277100；2枣庄市妇幼保健院检验科，枣庄 277100 |
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| 基金项目： | 2019年枣庄市妇幼保健院科研立项（049） |
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| 摘 要： | 目的 分析儿童肺炎克雷伯菌（Klebsiella pneumoniae，KP）感染的临床特征及耐药性，为预防和控制耐药的KP感染提供临床依据。方法 收集枣庄市妇幼保健院2019年1月至12月经细菌培养为KP感染的68例脓毒症儿童临床资料（男28例，女40例），按照KP耐药表型分为超广谱β-内酰胺酶（extended spectrum β-lactamases，ESBLs）阳性KP感染组、ESBLs阴性KP感染组，比较两组患儿预后、住院时间、治疗中使用抗生素级别、抗生素种类、机械通气等的差别。计数资料采用χ2检验或Fisher确切概率法，计量资料采用Mann-Whitney U检验。结果 ESBLs阳性KP感染组病死率高于ESBLs阴性KP感染组（3/23比0/45），住院时间长于ESBLs阴性KP感染组，使用抗生素种类多于ESBLs阴性KP感染组，使用碳青酶烯类率高于ESBLs阴性KP感染组，机械通气率高于ESBLs阴性KP感染组（均P<0.05）；两组住院史及抗生素暴露差异均无统计学意义（均P>0.05）。结论 ESBLs阳性KP感染与预后呈负相关性。
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| 关 键 词： | 肺炎克雷伯菌 感染 脓毒症 耐药 临床行为 |
| 收稿时间： | 2022-03-09 |
Study on biological behaviors in children with Klebsiella pneumoniaeinfection |
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| Shi Guixiu,Chen Haiying,Fei Xiukun,Zeng Qinghe,Yu Zhenzhen. Study on biological behaviors in children with Klebsiella pneumoniaeinfection[J]. International Medicine & Health Guidance News, 2022, 28(16): 2299-2302. DOI: 10.3760/cma.j.issn.1007-1245.2022.16.019 |
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| Authors: | Shi Guixiu Chen Haiying Fei Xiukun Zeng Qinghe Yu Zhenzhen |
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| Affiliation: | 1 Department of Infectious Diseases, ZaozhuangMaternal and Child Health Hospital, Zaozhuang 277100, China; 2 Departmentof Clinical Laboratory, Zaozhuang Maternal and Child Health Hospital, Zaozhuang277100, China |
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| Abstract: | Objective To analyze the clinical characteristics and bacterial drug resistance inchildren with Klebsiella pneumoniae (KP) infection, so as to provide clinicalevidences for prevention and control of KP infection. Methods The clinical data of 68 children with sepsis of KP infection werecollected from Zaozhuang Maternal and Child Health Hospital from January toDecember 2019 (28 males and 40 females). Antimicrobial susceptibility wastested with broth microdilution method. They were divided into an extendedspectrum β-lactamases (ESBLs) positive KP infection group and an ESBLs negativeKP infection group. The prognosis, length of hospital stay, grade ofantibiotics used in treatment, type of antibiotics, mechanical ventilation, andso on were compared between the two groups. χ2 test or Fisher exact probability method was used for the count data, andMann-Whitney U test was used for themeasurement data. Results The mortality of theESBLs-positive KP infection group was higher than that of the ESBLs-negative KPinfection group (3/23 vs. 0/45), the length of hospital stay was longer thanthat of the ESBLs-negative KP infection group, the number of antibiotics usedwas more than that of the ESBLs-negative KP infection group, the usage rate ofCarbapenms was higher than that of the ESBLs-negative KP infection group, andthe mechanical ventilation rate was higher than that of the ESBLs-negative KPinfection group (all P<0.05).There were no statistically significant differences in the hospitalizationhistory and antibiotic exposure between the two groups (both P>0.05). Conclusion The infection of KP with ESBLs positive is negatively correlated withthe prognosis. |
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| Keywords: | Klebsiella pneumoniae Infection Sepsis Drug resistance Clinical behaviors |
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