| 靶向PD-1/PD-L1放射性核素分子探针及其在恶性肿瘤中的应用 |
| |
| 引用本文： | 张玉,杨梦蝶,余飞. 靶向PD-1/PD-L1放射性核素分子探针及其在恶性肿瘤中的应用[J]. 国际放射医学核医学杂志, 2022, 46(6): 374-379. DOI: 10.3760/cma.j.cn121381-202107003-00188 |
| |
| 作者姓名： | 张玉 杨梦蝶 余飞 |
| |
| 作者单位： | 同济大学附属第十人民医院核医学科 ，上海 200072 |
| |
| 摘 要： | 程序性细胞死亡受体1（PD-1）及其配体（PD-L1）免疫治疗已成为一种治疗多种恶性肿瘤的重要方法，但仅有部分患者临床获益，其影响因素之一是恶性肿瘤PD-1/PD-L1的表达水平。使用放射性核素标记完整单克隆抗体和抗体片段等制成靶向PD-1/PD-L1放射性核素分子探针进行显像，可无创、实时、动态地监测肿瘤PD-1/PD-L1的表达并量化其表达水平，进而筛选适宜治疗的患者、全面评估治疗疗效和预后。笔者综述了靶向PD-1/PD-L1放射性核素分子探针及其在恶性肿瘤中的应用。
|
| 关 键 词： | 放射性核素显像 分子探针 程序性细胞死亡受体1 B7-H1抗原 肿瘤 |
| 收稿时间： | 2021-07-07 |
Targeted PD-1/PD-L1 radionuclde molecular probes and its application in malignant tumors |
| |
| Yu Zhang,Mengdie Yang,Fei Yu. Targeted PD-1/PD-L1 radionuclde molecular probes and its application in malignant tumors[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2022, 46(6): 374-379. DOI: 10.3760/cma.j.cn121381-202107003-00188 |
| |
| Authors: | Yu Zhang Mengdie Yang Fei Yu |
| |
| Affiliation: | Department of Nuclear Medicine, the Tenth People's Hospital of Tongji University, Shanghai 200072, China |
| |
| Abstract: | Programmed cell death 1 receptor (PD-1) and its ligand (PD-L1) immunotherapy has become an important method for the treatment of a variety of malignant tumors, but only some patients have clinical benefits. One of the influencing factors is the expression level of PD-1/PD-L1 in malignant tumors. Radionuclide labeled complete monoclonal antibodies and antibody fragments are used to make targeted PD-1/PD-L1 radionuclide molecular probes for imaging, which can noninvasively, real-time, and dynamically monitor the expression of tumor PD-1/PD-L1 and quantify its expression level, so as to screen patients suitable for treatment and comprehensively evaluate the treatment efficacy and prognosis. The authors review the application of targeted PD-1/PD-L1 radionuclide molecular probes in malignant tumors. |
| |
| Keywords: | Radionuclide imaging Molecular probes Programmed cell death 1 receptor B7-H1 antigen Neoplasms |
|
| 点击此处可从《国际放射医学核医学杂志》浏览原始摘要信息 |
|
点击此处可从《国际放射医学核医学杂志》下载免费的PDF全文 |
