| 放射性皮肤纤维化的研究进展 |
| |
| 引用本文： | 莫韦,曹建平,余道江,张舒羽. 放射性皮肤纤维化的研究进展[J]. 国际放射医学核医学杂志, 2022, 46(8): 506-512. DOI: 10.3760/cma.j.cn121381-202111008-00203 |
| |
| 作者姓名： | 莫韦 曹建平 余道江 张舒羽 |
| |
| 作者单位： | 1.苏州大学放射医学与防护学院，放射医学与辐射防护国家重点实验室，苏州 215123;2.成都医学院第二附属医院，核工业四一六医院整形外科，成都 610051;3.四川大学华西基础医学与法医学院放射医学研究室，成都 610041 |
| |
| 摘 要： | 放射性皮肤纤维化是电离辐射作用于皮肤组织后的晚期效应，是放射性核事故和肿瘤放疗等之后常见的晚期并发症，严重影响患者的生活质量。放射性皮肤纤维化表现为皮肤外观的改变、皮肤弹性消失与挛缩、皮肤坚硬难以捏起折痕，可伴发毛细血管扩张、疼痛与瘙痒，部分患者甚至会发生进展性的纤维化，反复出现皮肤感染。目前关于放射性皮肤纤维化的发生机制尚不完全清楚，也缺乏针对性的救治手段及有效治疗药物。因此，深入探索电离辐射所致放射性皮肤纤维化的机制，寻找更有效的防治手段显得尤为重要。笔者就放射性皮肤纤维化的影响因素、临床表现、发生机制及其治疗方法等进行综述，并对其发展进行展望，旨在为放射性皮肤纤维化的研究提供参考。
|
| 关 键 词： | 辐射 皮肤损伤 放射性皮肤纤维化 |
| 收稿时间： | 2021-11-04 |
Research progress on radiation-induced skin fibrosis |
| |
| Wei Mo,Jianping Cao,Daojiang Yu,Shuyu Zhang. Research progress on radiation-induced skin fibrosis[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2022, 46(8): 506-512. DOI: 10.3760/cma.j.cn121381-202111008-00203 |
| |
| Authors: | Wei Mo Jianping Cao Daojiang Yu Shuyu Zhang |
| |
| Affiliation: | 1. State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China;2. Department of Plastic Surgery, Nuclear Industry 416 Hospital, the Second Affiliated Hospital of Chengdu Medical College, Chengdu 610051, China;3. Radiation Medicine Laboratory, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China |
| |
| Abstract: | Radiation-induced skin fibrosis is a late effect of radiation-induced skin injury. It is a common complication of tumor radiotherapy and radioactive nuclear accidents, which seriously affects the life quality of patients. Radiation-induced skin fibrosis is characterized by changes in skin appearance, loss of skin elasticity and contracture, hard skin and difficult to pinch creases, which may be accompanied by capillary dilatation, pain and itching. Some patients may even develop progressive fibrosis and recurrent skin infections. However, the mechanism of radiation-induced skin fibrosis is not completely clear at present, and there are no effective drugs and therapies to prevent or mitigate this disease. Therefore, it is particularly important to explore the mechanism of ionizing radiation-induced skin fibrosis and find more effective prevention and treatment methods. This article reviews the influencing factors, clinical manifestations, mechanism and treatment of radiation-induced skin fibrosis, and prospects its development, aiming to provide a reference for the research of radiation-induced skin fibrosis. |
| |
| Keywords: | Radiation Skin injury Radiation-induced skin fibrosis |
|
| 点击此处可从《国际放射医学核医学杂志》浏览原始摘要信息 |
|
点击此处可从《国际放射医学核医学杂志》下载免费的PDF全文 |
|
