| 血清IgG4水平升高的肥厚性硬脑膜炎患者的临床特征分析 |
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| 引用本文： | 叶锦龙 张伟劲 刘宝珠 李波 潘梦秋 匡祖颖 王展航. 血清IgG4水平升高的肥厚性硬脑膜炎患者的临床特征分析[J]. 国际医药卫生导报, 2022, 28(15): 2166-2169. DOI: 10.3760/cma.j.issn.1007-1245.2022.15.021 |
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| 作者姓名： | 叶锦龙 张伟劲 刘宝珠 李波 潘梦秋 匡祖颖 王展航 |
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| 作者单位： | 1广东三九脑科医院神经内科，广州 510510；2广州医科大学附属第二医院神经内科，广州 510260 |
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| 摘 要： | 目的 探索以血清免疫球蛋白（Ig）G4水平升高的肥厚性硬脑膜炎患者的临床特征。方法 收集2018年1月至2021年1月在广东三九脑科医院住院治疗的20例血清IgG4水平升高的肥厚性硬脑膜炎患者并回顾性分析其临床资料。结果 20例患者中，女9例、男11例，发病年龄（50.8±16.5）岁。患者的主要临床表现为头痛［90.0%（18/20）］、视力下降［35.0%（7/20）］、视物重影［25.0%（5/20）］、耳鸣［25.0%（5/20）］、发热［20.0%（4/20）］、癫痫［20.0%（4/20）］、眼睑下垂［15.0%（3/20）］、肢体无力［10.0%（2/20）］。所有患者头颅MR增强提示硬脑膜强化且血清中IgG4水平升高。结论 以血清中IgG4升高的肥厚性硬脑膜炎在磁共振成像的表现主要以累及硬脑膜为主，可有颅骨破坏及大脑皮层浸润性损害。在临床怀疑为肥厚性硬脑膜炎患者，建议完善血清IgG4检测，必要时可进一步病理学活检以明确诊断。
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| 关 键 词： | 脑膜炎 IgG4相关性肥厚性脑膜炎 磁共振成像 临床特点 IgG4相关性疾病 |
| 收稿时间： | 2022-04-29 |
Clinical features of patients with hypertrophic pachymeningitis andincreased serum IgG4 |
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| Ye Jinlong,Zhang Weijing,Liu Baozhu,Li Bo,Pan Mengqiu,Kuang Zuying,Wang Zhanhang. Clinical features of patients with hypertrophic pachymeningitis andincreased serum IgG4[J]. International Medicine & Health Guidance News, 2022, 28(15): 2166-2169. DOI: 10.3760/cma.j.issn.1007-1245.2022.15.021 |
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| Authors: | Ye Jinlong Zhang Weijing Liu Baozhu Li Bo Pan Mengqiu Kuang Zuying Wang Zhanhang |
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| Affiliation: | 1 Department of Neurology, Guangdong 999 Brain Hospital, Guangzhou510510, China;2 Department of Neurology, Second Hospital, GuangzhouMedical University, Guangzhou 510260, China |
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| Abstract: | Objective To explore the clinical features of patients with hypertrophicperimeningitis and increased serum IgG4. Methods Twenty patients withhypertrophic pachymeningitis and increased serum IgG4 who were hospitalized inGuangdong 999 Brain Hospital from January 2018 to January 2021 were collected,and their clinical data were retrospectively analyzed. Results Among the 20 patients, there were 9 females and 11 males. The age ofonset was (50.8±16.5). Their main clinical manifestations were headache [90.0%(18/20)], decreased vision [35.0% (7/20)], diplopia [25.0% (5/20)], tinnitus[25.0% (5/20)], fever [20.0% (4/20)], epilepsy [20.0% (4/20)], drooping eyelids[15.0% (3/20)], and limb weakness 10.0% (2/20). The enhancement of cranial MRin all the patients indicated that the dura mater was strengthened and theserum level of IgG4 was elevated. Conclusions Hypertrophic pachymeningitis with elevated serum IgG4 has various MRImanifestations, mainly involving the dura mater, and could be combined withskull destruction and cerebral cortex infiltration damage. All patientsconsidering the diagnosis of hypertrophic pachymeningitis should detect serumIgG4, and take meningeal biopsy if it is necessary to further confirm thediagnosis. |
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| Keywords: | Meningitis IgG4-related hypertrophic pachymeningitis Magnetic resonance imaging Clinical features IgG4-related diseases |
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