Synthesis of the olanzapine labeled by carbon‐14 |
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| Authors: | Naghi Saadatjoo Mohsen Javaheri Nader Saemian Mohsen Amini |
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| Affiliation: | 1. Department of Organic Chemistry, Faculty of Chemistry, Semnan University, Semnan, Iran;2. Applied Radiations Research School, Nuclear Science & Technology Research Institute, Tehran, Iran;3. Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design & Development Research Center, Tehran University of Medical Sciences, Tehran, Iran |
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| Abstract: | Olanzapine is one of the most widely used antipsychotic drugs, which acts as an antagonist for multiple neurotransmitter receptor sites. 2‐Methyl‐4‐(4‐methyl‐1‐piperazinyl)‐10H‐thieno [2,3‐b][1,5] benzodiazepine (Olanzapine) labeled with carbon‐14 in the four positions has been synthesized as part of a three‐step sequence from 2‐amino‐5‐methylthiophene‐3‐carbonitrile‐[carbonitrile‐14C]. |
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| Keywords: | olanzapine carbon‐14 antipsychotic |
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