| 不同射频温度及时间对大鼠坐骨神经运动传导速度的影响 |
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| 引用本文： | 罗高权,刘晓加,彭凯润,刘雁,杨红军,杨忠民. 不同射频温度及时间对大鼠坐骨神经运动传导速度的影响[J]. 南方医科大学学报, 2010, 30(3): 579 |
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| 作者姓名： | 罗高权 刘晓加 彭凯润 刘雁 杨红军 杨忠民 |
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| 作者单位： | 南方医科大学研究生学院广州军区总医院神经内科,广东,广州,510010;南方医科大学南方医院神经内科,广东广州,510515;广州军区总医院神经内科,广东,广州,510010 |
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| 摘 要： | 目的解剖大鼠坐骨神经,使用不同的射频热凝温度及作用时间,观察不同状态下坐骨神经运动传导速度(MCV)潜伏期、峰-峰值、负相波面积作用前后的变化。方法解剖70只成年SD大鼠双侧坐骨神经,分组予以30、50、55、60、70℃不同射频热凝作用时间,另30～50℃每隔5℃一组予以60s射频热凝作用时间,观测处理前后坐骨神经MCV各参数变化情况。结果不同温度射频热凝作用前后MCV各参数均有显著性差异(P<0.05)(除55℃10s时);50℃以下处理组处理前后MCV与射频作用时间并无相关关系;55℃不同时间组,除55℃处理组15、20、25、30s时处理后潜伏期与时间无相关关系及50s以上无法测出数据外,其余处理后潜伏期与时间呈显著正相关,峰-峰值、负相波面积与时间呈显著负相关;60s不同温度组(50℃以下)与MCV各参数呈正相关;55℃50s以及60℃10s以上处理组无法测出MCV。结论低温射频热凝(50℃以下)对于MCV有明确影响,与时间无相关关系,机制尚不明确;同时予以一定温度的射频热凝,只要予以适当够长的热凝时间,同样可以取得完全阻滞MCV的作用;当予以高温射频时,阻断神经传导的效果是肯定的。
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| 关 键 词： | 射频 热凝 坐骨神经 运动传导速度 |
Effect of radiofrequency of different temperatures and durations on motor conduction velocity of rat sciatic nerve |
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| LUO Gao-quan,LIU Xiao-jia,PENG Kai-run,LIU Yan,YANG Hong-jun,YANG Zhong-min. Effect of radiofrequency of different temperatures and durations on motor conduction velocity of rat sciatic nerve[J]. Journal of Southern Medical University, 2010, 30(3): 579 |
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| Authors: | LUO Gao-quan LIU Xiao-jia PENG Kai-run LIU Yan YANG Hong-jun YANG Zhong-min |
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| Affiliation: | LUO Gao-quan1,2,LIU Xiao-jia3,PENG Kai-run2,LIU Yan2,YANG Hong-jun2,YANG Zhong-min2 Postgraduate School1,Department of Neurology,Nanfang Hospital3,Southern Medical University,Guangzhou 510515,China,2Department of Neurology,General Hospital of Guangzhou Military Comm,,Guangzhou 510010 |
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| Abstract: | Objective To evaluate the effect of radiofrequency of different temperatures and durations on sciatic nerve motor conduction velocity (MCV). Methods The bilateral sciatic nerve of 70 adult SD rats was dissected and exposed to radiofrequency ablation of different temperatures (30, 50, 55, 60, and 70 ℃) and durations. The nerves were also exposed to increasing ablation temperatures from 30℃ to 50℃ with an increment of 5℃ (60 s at each temperature), and the changes inthe MCV parameters were observed. Results The MCV parameters of rat sciatic nerve underwent significant changes following the radiofrequency exposures (P<0.05) except for the exposure at 55℃ for 10 s. Below the temperature of 55℃, the MCV showed no obvious correlation to the exposure time for the group. For the nerves exposed to radiofrequency of 55℃,the latency was not correlated to the exposure time within 30 s, and data could be obtained from 55 s group; with theseexceptions, the latency was found to positively while the negative phase wave inversely correlated to the exposure time. Withfixed exposure time of 60 s, the MCV parameters were positively correlated to the ablation temperature (below 50℃). Failure of MCV measurement occurred following exposures to 55℃ for 50 s (or longer) or to 60℃ (or higher) for 10 s. Conclusion Low-temperature radiofrequency (below 50℃) produces definite effects on the MCV of rat sciatic nerve, and the effects are not associated with the exposure time, the mechanism of which remains unclear. At a given temperature, the ablation for sufficiently long durations can result in complete block of the MCV. At higher temperatures, radiofrequeney exposure cause obvious nerve conduction block. |
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| Keywords: | radiofrequency thermocoaglulation sciatic nerve motor nerve conduction velocity |
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