| LC3B在口腔扁平苔藓组织及其T细胞中的表达 |
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| 引用本文： | 张娜,张静,谭雅芹,杜格非,卢锐,周刚. LC3B在口腔扁平苔藓组织及其T细胞中的表达[J]. 口腔医学研究, 2016, 32(12): 1257. DOI: 10.13701/j.cnki.kqyxyj.2016.12.008 |
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| 作者姓名： | 张娜 张静 谭雅芹 杜格非 卢锐 周刚 |
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| 作者单位： | 武汉大学口腔医学院口腔黏膜科 湖北 武汉 430079 |
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| 基金项目： | 国家自然科学基金项目(编号:81371147) |
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| 摘 要： | 目的:检测微管相关蛋白1轻链3B(LC3B)在口腔扁平苔藓(oral lichen planus, OLP)局部组织及其T细胞中的表达。方法:分别采用免疫组织化学染色和多色免疫荧光染色方法检测自噬相关蛋白LC3B在OLP局部组织及其T细胞中的表达,并分析LC3B与OLP临床特征之间的关系。结果:LC3B在OLP局部组织及病损T细胞中的表达显著高于对照组(P<0.001,P<0.01),且与RAE计分呈负相关(P<0.05,P<0.01)。LC3B在非糜烂型OLP组织中的表达显著高于糜烂型OLP(P<0.01)。结论:自噬相关蛋白LC3B可能参与了OLP的局部免疫机制。
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| 关 键 词： | 口腔扁平苔藓 LC3B 组织 T细胞 表达 |
| 收稿时间： | 2016-10-11 |
Expression of LC3B in Local Tissues and T Cells of Oral Lichen Planus. |
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| ZHANG Na,ZHANG Jing,TAN Ya-qin,DU Ge-fei,LU Rui,ZHOU Gang. Expression of LC3B in Local Tissues and T Cells of Oral Lichen Planus.[J]. Journal of Oral Science Research, 2016, 32(12): 1257. DOI: 10.13701/j.cnki.kqyxyj.2016.12.008 |
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| Authors: | ZHANG Na ZHANG Jing TAN Ya-qin DU Ge-fei LU Rui ZHOU Gang |
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| Affiliation: | School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China |
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| Abstract: | Objective: To investigate the expression level of autophagy-related protein LC3B in local tissues and T cells of oral lichen planus (OLP). Methods: The expression of autophagy-related protein LC3B in OLP local tissues and T cells was investigated by immunohistochemistry and multi-color immunofluorescence staining, respectively. In addition, the associations between LC3B and the clinical features of OLP were analyzed. Results: The expression of LC3B in OLP local tissues and T cells was significantly increased compared with that in controls (P<0.001, P<0.01, respectively), and was negatively correlated with the RAE scores of OLP patients (P<0.05, P<0.01, respectively). Besides, the expression of LC3B in nonerosive OLP tissues was higher than that in erosive OLP tissues (P<0.01). Conclusion: LC3B may participate in the local immunopathogenesis of OLP. |
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| Keywords: | Oral lichen planus LC3B Tissues T cells Expression |
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