| 卵巢交界性上皮性肿瘤 112 例临床分析 |
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| 引用本文： | 杨文,王颖梅,刘国艳,闫晔,马学功,薛凤霞△. 卵巢交界性上皮性肿瘤 112 例临床分析[J]. 天津医药, 2016, 44(9): 1092-1094. DOI: 10.11958/20160056 |
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| 作者姓名： | 杨文 王颖梅 刘国艳 闫晔 马学功 薛凤霞△ |
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| 作者单位： | 天津医科大学总医院妇产科（邮编 300052） |
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| 基金项目： | 国家自然科学基金青年项目（81402141）；天津市应用基础与前沿技术研究计划（15JCYBJC26600） |
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| 摘 要： | 目的 探讨卵巢交界性上皮性肿瘤的临床特点及影响复发的相关因素。 方法 回顾性分析天津医科大学总医院 2000 年 3 月—2015 年 1 月收治的 112 例卵巢交界性上皮性肿瘤的临床资料。 结果 112 例患者发病的平均年龄为（50.59±16.90）岁。 FIGO 临床分期Ⅰ 期 102 例（91.07%）， Ⅱ 期 4 例（3.57%）， Ⅲ期 6 例（5.36%）； 血清肿瘤标志物检查： 行 CA125 检查患者 102 例， 其中指标升高者 27 例， 占 26.47%；112 例患者均进行手术治疗， 年轻患者较年长患者更倾向于选择保守手术治疗； 随访患者 97 例， 其中 5 例复发， 复发病例均行非保留生育功能手术。 对不同临床病理因素下复发的病例进行对比， 病理提示微浸润患者复发率高于无微浸润患者［37.50%（3/8） vs. 2.25%（2/89）， P=0.004］； 在浆液性交界性肿瘤患者中， 微乳头型交界性浆液性肿瘤的复发率高于非微乳头型［40.00%（2/5） vs. 0（0/ 41），P=0.019］； 7 例行保留生育功能手术的患者成功妊娠。 结论 对于年轻有生育要求的卵巢交界性上皮性肿瘤患者可选择保留生育功能手术， 结局安全有效。 对于存在间质微浸润及微乳头型患者要警惕复发的可能。
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| 关 键 词： | 卵巢肿瘤 妇科外科手术 预后 卵巢交界性上皮性肿瘤 |
| 收稿时间： | 2016-02-14 |
| 修稿时间： | 2016-04-21 |
The clinical analysis of 112 cases with ovarian borderline epithelial tumors#br##br# |
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| YANG Wen,WANG Yingmei,LIU Guoyan,YAN Ye,MA Xuegong,XUE Fengxia△. The clinical analysis of 112 cases with ovarian borderline epithelial tumors#br##br#[J]. Tianjin Medical Journal, 2016, 44(9): 1092-1094. DOI: 10.11958/20160056 |
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| Authors: | YANG Wen WANG Yingmei LIU Guoyan YAN Ye MA Xuegong XUE Fengxia△ |
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| Affiliation: | Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin 300052, China
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| Abstract: | Objective To determine the clinical features and the factors affecting the recurrence of ovarian borderline epithelial tumors. Methods A retrospective data of 112 cases with ovarian borderline epithelial tumors admitted in General Hospital of Tianjin Medical University from 2000 to 2015 were analyzed. Results The average age was (50.59±16.90) years in 112 patients with FIGO stage Ⅰ of 102 (91.07%) patients, stage Ⅱ of 4 (3.57%) and stage Ⅲ of 6 (5.36%). The serum tumor marker (CA125) was examined in 102 patients, and 27 cases with the elevated indicator (26.47%). Surgical treatment was performed in 112 patients. Younger patients were more likely to choose conservative surgery. Ninety-seven patients were followed up, and 5 of them relapsed. Non fertility preserving surgery was performed in patients with recurrence. The recurrence rates of patients with different clinical pathological factors were compared. The recurrence rate was higher in patients with micro infiltration than that of patients without micro infiltration [37.50% (3/8) vs. 2.25% (2/89), P=0.004]. And the recurrence rate was higher in patients with microemulsion type borderline serous tumor than that of patients with non-papillary tumors [40.00%（2/5） vs. 0（0/41）， P= 0.019]. Seven patients underwent conservative surgery had normal spontaneous pregnancy. Conclusion The fertility-sparing surgery can be used as the treatment procedures for young patients, which is safe and effective. It is necessary to be on alert of recurrence for the cases with micropapillary pattern, and microinvasive tumor. |
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| Keywords: | ovarian neoplasms gynecologic surgical procedures prognosis epithelialborderline ovarian tumors |
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