| 氨氯地平联合培哚普利对老年原发性高血压患者血压变异性的影响 |
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| 引用本文： | 潘春奇,王琳,刘文民. 氨氯地平联合培哚普利对老年原发性高血压患者血压变异性的影响[J]. 中华全科医学, 2016, 14(8): 1335-1337. DOI: 10.16766/j.cnki.issn.1674-4152.2016.08.030 |
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| 作者姓名： | 潘春奇 王琳 刘文民 |
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| 作者单位： | 杭州师范大学附属医院心血管内科, 浙江 杭州 310015 |
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| 摘 要： | 目的 观察氨氯地平联合培哚普利对老年原发性高血压患者血压变异性的影响。 方法 选择2014年10月—2015年10月在杭州师范大学附属医院就诊的老年原发性高血压患者82例，按照随机数字法分为观察组、对照组，每组41例，对照组给予氨氯地平(2片/d)进行治疗，观察组给予氨氯地平(1片/d)联合培哚普利(1片/d)进行治疗，2组均治疗8周，分别于治疗前及治疗后采用无创便携式动态血压监测仪监测2组24 h动态血压，通过计算血压变异性指标(标准差SD和变异系数CV)来评估血压变异性。 结果 对照组治疗后24 h、白天及晚上的收缩压和舒张压SD均较治疗前明显降低(P＜0.05)；观察组治疗后24 h、白天及晚上收缩压和舒张压SD及CV均显著性下降(P＜0.05)，但观察组24 h、白天收缩压和舒张压SD及CV均显著性低于对照组(P＜0.05)；观察组总有效率为95.1%，显著高于对照组的78.0%(Z=-3.86，P＜0.05)；治疗期间2组血、尿常规，心、肝、肾功能均在正常范围内。观察组不良反应发生率为6.67%，显著低于对照组的17.1%(χ2=5.615，P＜0.05)。 结论 氨氯地平联合培哚普利可有效降低老年原发性高血压患者24 h收缩压及舒张压变异性，临床疗效好，不良反应低，值得临床推广。
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| 关 键 词： | 氨氯地平 培哚普利 血压变异性 联合用药 |
| 收稿时间： | 2016-01-25 |
Blood pressure viability after using amlodipine combined with perindopril in Elderly Patients with Essential Hypertension |
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| Affiliation: | Department of Cardiology,the Affiliated Hospital of Hangzhou Normal University,Hangzhou,Zhejiang 310015,China |
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| Abstract: | Objective To observe the influence of amlodipine combined with perindopril on blood pressure viability(BPV) in elderly patients with essential hypertension. Methods From October,2014 to October,2015 in our hospital,82 patients with essential hypertension(EH) were divided into observation group and control group according to the random numbers(41 cases in each group). The control group were given amlodipine(10 mg/d),the observation group were given amlodipine(5 mg/d) combined with perindopril(4 mg/d),both groups were treated for eight weeks. 24 h ambulatory blood pressure was measured with noninvasive portable ambulatory blood pressure monitoring before and after the treatment. BPV was assessed using the standard deviation(SD) and coefficient variation(CV). Results In the control group,the SD for the systolic and diastolic blood pressure during the day and night at 24 h after the treatment day night were significantly lower than that before the treatment(P < 0. 05); While in the observation group,the SD and CV for the systolic and diastolic blood pressure during the day and night at 24 h after the treatment day night decreased significantly as compared with that before the treatment(P < 0. 05); After the treatment,both SD and CV in the observation group were lower than those in the control group(P < 0. 05). The total effective rate was 95. 1% in the observation group,which was significantly higher than 78. 0% in the control group(Z=- 3. 86,P < 0. 05); During the treatment,the routine urine and blood test results,functions of heart,liver and kidney were all within the normal range in both groups. And in the observation group,the incidence of adverse reactions was 6. 67%,which was significantly lower than 17. 1% in the control group(χ2=5. 615,P < 0. 05). Conclusion Amlodipine combined with perindopril can effectively reduce BPV of 24 hours systolic and diastolic blood pressure,with better curative efficacy and lower incidence of adverse reactions,and worthy of further promotion in clinics. |
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