| 改良电抽搐治疗对抑郁发作患者甲状腺功能和性激素的影响 |
| |
| 引用本文： | 汤晨东,沈小燕,郑瑶,査显友,李亚玲,李国荣,唐建良. 改良电抽搐治疗对抑郁发作患者甲状腺功能和性激素的影响[J]. 中华全科医学, 2016, 14(7): 1129-1131. DOI: 10.16766/j.cnki.issn.1674-4152.2016.07.022 |
| |
| 作者姓名： | 汤晨东 沈小燕 郑瑶 査显友 李亚玲 李国荣 唐建良 |
| |
| 作者单位： | 嘉兴市康慈医院精神科, 浙江 嘉兴 314500 |
| |
| 基金项目： | 浙江省桐乡市科技计划项目(201302045) |
| |
| 摘 要： | 目的 探讨抑郁发作患者接受改良电抽搐治疗(modified electroconvulsive therapy，MECT)后甲状腺功能和性激素的变化。 方法 选择符合ICD-10诊断标准的抑郁发作患者57例，采用化学发光免疫法分别检测MECT治疗后30 min和疗程结束后的血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺功能(FT4)、促甲状腺功能(TSH)、三碘甲状腺原氨酸(T3)、甲状腺功能(T4)、睾酮(T)、雌二醇(E2)及血清泌乳素(PRL)。采用汉密尔顿抑郁量表17项版(Hamilton Depression Rating Scale，HAMD)对治疗前后的抑郁发作患者进行症状严重程度评定。分析甲状腺功能及性激素与HAMD评分的相关性。 结果 MECT治疗后30 min，甲状腺功能无明显变化(P＞0.05)，E2水平显著下降(P＜0.01)，PRL水平显著升高(P＜0.01)。MECT疗程结束后,T3、FT3和E2水平显著增高(P＜0.01)。MECT治疗前后T3水平与HAMD中阻滞因子负相关(r=-0.480,r=-0.471，P＜0.01)，T水平与HAMD中阻滞因子负相关(r=-0.412,r=-0.385，P＜0.01)，其他甲状腺功能和性激素与HAMD评分各因子分无相关。 结论 经MECT治疗的抑郁发作患者可以监测其甲状腺功能水平及性激素水平，以便于临床医生观察疗效和调整治疗方案。
|
| 关 键 词： | MECT 抑郁发作 甲状腺功能 性激素 |
| 收稿时间： | 2015-03-10 |
Effect of modified electroconvulsive therapy on thyroxine and sex-hormone of patients experiencing an episode of depression |
| |
| Affiliation: | Department of Psychiatry, Kangci Hospital of Jiaxing, Jiaxing, Zhejiang 314500, China |
| |
| Abstract: | Objective To explore the effect of modified electroconvulsive therapy(MECT) on thyroxine and sex-hormone of the of patients experiencing an episode of depression. Methods Fifty-seven patients meeting the criteria of ICD-10 for depression episode were enrolled into the study.The levels of serum free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH),triiodothyronine(T3),thyroxine(T4),testosterone(T),estradiol(E2) and prolactin(PRL) were tested at 30-minutes after the treatment and the end of treatment.Hamilton Depression Rating Scale(HAMD) was performed before and after the treatment to assessseverity of symptom.The correlations among thyroxine,sex-hormone and scores of HAMD were analyzed. Results Thyroxine had no significant changes,E2 was significantly decreased 30-minutes after the treatment(P<0.01),while PRL was significantly increased after that(P<0.01).T3,FT3 and E2were significantly increased at the end of the treatment(P<0.01).There was significant negative correlation between level of T3 and scores of retardation factor before and after the treatment(r=-0.480,r=-0.471,P<0.01).There was significant negative correlation between level of T and scores of retardation factor before and after the treatment(r=-0.412,r=-0.385,P<0.01) while no correlation among other thyroxine,Sex-hormone and scores of HAMD. Conclusion The clinical doctors can evaluate the efficacy and adjust treatment plan based on the levels of thyroxine and sex-hormone in depressive episodes patients receiving MECT. |
| |
| Keywords: | |
|
| 点击此处可从《中华全科医学》浏览原始摘要信息 |
|
点击此处可从《中华全科医学》下载免费的PDF全文 |
|
