| 近年来发展抗血吸虫新药的进展 |
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| 引用本文： | 肖树华. 近年来发展抗血吸虫新药的进展[J]. 中国寄生虫学与寄生虫病杂志, 2010, 28(3): 218-225 |
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| 作者姓名： | 肖树华 |
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| 作者单位： | 中国疾病预防控制中心寄生虫病预防控制所,卫生部寄生虫病原与媒介生物学重点实验室,世界卫生组织疟疾、血吸虫病和丝虫病合作中心,上海 200025 |
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| 摘 要： | 全球有2亿人感染血吸虫,其治疗仅依赖吡喹酮一种药物是很不相适应的。吡喹酮虽有很好的治疗效果,但无预防作用,故发展抗血吸虫新药倍受关注。本文综述近年来报道的恶二唑-2-氧化物和甲氟喹等抗血吸虫新药的实验研究,阐述这些药物的发展过程,及其抗血吸虫特点。
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| 关 键 词： | 血吸虫 血吸虫病 恶二唑-2-氧化物 甲氟喹 吡喹酮 |
Progress in Development of New AntischistosomalDrugs in Recent Years |
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| XIAO Shu-hua. Progress in Development of New AntischistosomalDrugs in Recent Years[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2010, 28(3): 218-225 |
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| Authors: | XIAO Shu-hua |
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| Affiliation: | National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention;Key Laboratory of Parasite and Vector Biology,MOH;WHO collaborating Center for Malaria,Schistosomiasis and Filariasis,Shanghai 200025,China |
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| Abstract: | 【Abstract】 It is estimated that 200 million people have suffered the infection with schistosomes in the world. The fact that treatment of schistosomiasis only relies on a single drug praziquantel does not adapt to the demand. Although praziquantel exhibits excellent therapeutic efficacy, it shows no preventive action to the infection. Therefore, development of new anti-schistsomal drugs has been received serious attention. In this paper the recent development of new anti-schistosomal drugs such as oxadiazole-2-oxides, mefloquine, etc. has been reviewed, and the process of their development and anti-schistosomal properties recounted. |
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| Keywords: | Schistosome Schistosomiasis Oxadizole-2-oxides Mefloquine Praziquantel')" >Schistosome Schistosomiasis Oxadizole-2-oxides Mefloquine Praziquantel |
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