Amnioserosa development and function in Drosophila embryogenesis: Critical mechanical roles for an extraembryonic tissue |
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| Authors: | Monica E. Lacy M. Shane Hutson |
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| Affiliation: | 1. Department of Physics & Astronomy, Vanderbilt University, Nashville, Tennessee;2. Vanderbilt Institute for Integrative Biosystems Research & Education, Vanderbilt University, Nashville, Tennessee |
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| Abstract: | Despite being a short‐lived, extraembryonic tissue, the amnioserosa plays critical roles in the major morphogenetic events of Drosophila embryogenesis. These roles involve both cellular mechanics and biochemical signaling. Its best‐known role is in dorsal closure—well studied by both developmental biologists and biophysicists—but the amnioserosa is also important during earlier developmental stages. Here, we provide an overview of amnioserosa specification and its role in several key developmental stages: germ band extension, germ band retraction, and dorsal closure. We also compare embryonic development in Drosophila and its relative Megaselia to highlight how the amnioserosa and its roles have evolved. Placed in context, the amnioserosa provides a fascinating example of how signaling, mechanics, and morphogen patterns govern cell‐type specification and subsequent morphogenetic changes in cell shape, orientation, and movement. Developmental Dynamics 245:558–568, 2016. © 2016 Wiley Periodicals, Inc. |
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| Keywords: | amnioserosa morphogenesis Drosophila embryogenesis tissue mechanics amnion serosa evolution biophysics specification |
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