| 胃癌组织mdr1基因表达的临床意义 |
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| 引用本文： | 刘忠民,寿楠海. 胃癌组织mdr1基因表达的临床意义[J]. 世界华人消化杂志, 1999, 0(2): 145-146 |
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| 作者姓名： | 刘忠民 寿楠海 |
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| 作者单位： | 1. 山东省泰安市中心医院普外科,271000
2. 山东医科大学第一附属医院普外科,山东省,济南市,250012 |
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| 摘 要： | 目的探讨多药耐药基因（ｍｄｒ１基因）在人胃癌组织中的表达及其与临床病理的关系．方法应用ＲＴＰＣＲ法检测了２９例手术切除人胃癌组织中的ｍｄｒ１ｍＲＮＡ．术前未用过化疗．结果ｍｄｒ１ｍＲＮＡ的阳性率为４８３％（１４／２９），ｍｄｒ１ｍＲＮＡ的表达在肿瘤浸润浆膜者为３３３％（７／２１），明显低于未浸润浆膜者（７／８），基因的表达与年龄、性别、肿瘤大小、组织学类型、淋巴结转移及ＴＮＭ分期等无关．结论化疗前胃癌组织中ｍｄｒ１基因即存在较高的表达率，这为选用化疗药物和ＭＤＲ逆转剂提供了参考指标．ｍｄｒ１ｍＲＮＡ表达减少似与肿瘤进展相关．
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| 关 键 词： | 胃肿瘤 多药耐受性 mdr1基因 RNA,信使 基因表达 |
| 修稿时间： | 1998-06-29 |
Significance of mdr1 gene expression in gastric carcinoma tissue |
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| LIU Zhong-Min,SHOU Nan-Hai. Significance of mdr1 gene expression in gastric carcinoma tissue[J]. World Chinese Journal of Digestology, 1999, 0(2): 145-146 |
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| Authors: | LIU Zhong-Min SHOU Nan-Hai |
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| Abstract: | AIM To explore the relationship between expression of mdr1 gene in human gastric cancer and clinicopathological changes. METHODS From Sept 1997 to Jan 1998, a total of 29 patients with gastric carcinoma were recruited, and mdr1 mRNA were assayed by RT PCR. Fresh tumor tissues were surgically resected without chemotherapy before operation. RESULTS The positive rate of mdr1 mRNA was 48 3% (14/29). The expression rate in patients with serosa invasion was 33 3% (7/21), much lower than in those without serosa invasion (87 5%). The correlation between mdr1 expression and the age and sex of the patients, tumor size, histologic types, lymph node involvement and TNM stage was not significant. CONCLUSION There are intrinsic drug resistance in almost half of the primary gastric carcinomas prior to chemotherapy. Analysis of mdr1 gene can be helpful in selecting chemotherapeutic drugs and mdr1 mRNA may act as a reference index for using the MDR reversing agents. The absence of mdr1 mRNA expression seems to correlate with advanced disease, which needs to be further confirmed. |
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| Keywords: | stomach neoplasms resistance multiple drugs mdr1 gene RNA messenger gene expression |
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