| 乏氧微环境下外泌体对肿瘤进展及辐射抵抗的影响 |
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| 引用本文： | 默芳,张江虹,邵春林. 乏氧微环境下外泌体对肿瘤进展及辐射抵抗的影响[J]. 国际放射医学核医学杂志, 2019, 43(5): 450-455. DOI: 10.3760/cma.j.issn.1673-4114.2019.05.012 |
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| 作者姓名： | 默芳 张江虹 邵春林 |
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| 作者单位： | 复旦大学放射医学研究所放射生物研究部，上海 200032 |
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| 基金项目： | 国家自然科学基金;National Natural Science Foundation of China |
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| 摘 要： | 肿瘤的发生发展是一个复杂的生物学过程，涉及诸多的因素。乏氧是实体肿瘤微环境的显著特征之一，乏氧微环境可导致肿瘤的适应性更强、恶性程度更高并产生耐药性。研究发现，外泌体是介导肿瘤生物学过程的重要因子，而乏氧环境下产生的外泌体在某些生物学过程中的作用更为显著。因而，研究乏氧环境下外泌体对了解肿瘤的发展进程，控制肿瘤的生长具有重要意义。笔者简单概述了外泌体在肿瘤乏氧微环境中的作用，以期为肿瘤生物学的研究提供一定的理论基础。
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| 关 键 词： | 肿瘤乏氧 外泌体 肿瘤 辐射抵抗 |
| 收稿时间： | 2019-01-19 |
The effect of exosome in hypoxic microenvironment on tumor progression and radioresistance |
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| Fang Mo,Jianghong Zhang,Chunlin Shao. The effect of exosome in hypoxic microenvironment on tumor progression and radioresistance[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2019, 43(5): 450-455. DOI: 10.3760/cma.j.issn.1673-4114.2019.05.012 |
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| Authors: | Fang Mo Jianghong Zhang Chunlin Shao |
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| Affiliation: | Department of Radiation Biology, Institute of Radiation Medicine, Fudan University, Shanghai 200032, China |
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| Abstract: | The development and progression of tumor is a complex biological process, involving many factors. Hypoxia is one of the prominent features of the microenvironment of solid tumors. Hypoxic microenvironment can contribute to tumors with stronger adaptability, higher malignancy and drug-resistance. The study found that exosomes are important factors in mediating tumor biological processes, while hypoxic-derived exosomes play a more prominent role in some biological processes. Therefore, researches on hypoxic-derived exosomes are of great importance in understanding the development and growth control of tumors. This article briefly outlines the role of exosomes in tumor hypoxic microenvironment, in order to provide a theoretical basis for the researches of tumor biology. |
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| Keywords: | Tumor hypoxia Exosomes Tumor Radioresistance |
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