| 北海市孕妇碘营养及甲状腺激素水平调查分析 |
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| 引用本文： | 苏会璇,钟宇华,梁华晟,韦慈,连冬梅. 北海市孕妇碘营养及甲状腺激素水平调查分析[J]. 新乡医学院学报, 2010, 27(4): 342-344 |
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| 作者姓名： | 苏会璇 钟宇华 梁华晟 韦慈 连冬梅 |
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| 作者单位： | 广西医科大学第九附属医院内分泌科;广西医科大学第九附属医院妇产科 |
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| 基金项目： | 北海市科技计划课题资助，吴阶平医学基金会课题资助 |
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| 摘 要： | 目的探讨妊娠对孕妇碘营养状况、甲状腺激素水平的影响,为北海市孕妇人群适宜碘营养的指导提供理论依据。方法采用ACS-180化学发光分析仪检测837例孕妇的血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)和人绒毛膜促性腺激素(HCG);利用碘催化砷铈反应原理,采用冷消解快速尿碘定量检测方法测定孕妇一次随意尿的尿碘含量。结果 837例孕妇尿碘中位数为224μg.L-1,尿碘≤100μg.L-1的比率为18.52%,<50μg.L-1的比率为5.26%;孕早、中、晚期孕妇尿碘中位数分别为142、147、298μg.L-1,孕早、中期的低尿碘率高于孕晚期(P<0.01)。孕早、中期的FT3、FT4和HCG高于孕晚期(P<0.05),而TSH低于孕晚期(P<0.05)。高尿碘组FT3、FT4和HCG低于低尿碘组(P<0.05),2组TSH比较差别无统计学意义(P>0.05)。结论北海市孕妇人群不存在碘缺乏,但孕早、中期孕妇存在碘摄入不足;孕晚期的甲状腺功能相对孕早、中期而言处于一种轻微甲状腺功能减低的代偿状态;碘营养过剩亦可使孕妇的甲状腺激素水平降低。
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| 关 键 词： | 尿碘 甲状腺激素 碘营养 孕妇 |
Survey on iodine nutrition and thyroid hormones levels of the pregnant in Beihai city |
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| SU Hui-xuan,ZHONG Yu-hua,LIANG Hua-sheng,WEI Ci,LIAN Dong-mei. Survey on iodine nutrition and thyroid hormones levels of the pregnant in Beihai city[J]. Journal of Xinxiang Medical College, 2010, 27(4): 342-344 |
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| Authors: | SU Hui-xuan ZHONG Yu-hua LIANG Hua-sheng WEI Ci LIAN Dong-mei |
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| Abstract: | Objective To investigate the influences of pregnance on iodine nutrition and thyroid hormones in the pregnant to provide a theoretical basis for the guidance of suitable iodine nutrition for the pregnant in Beihai.Methods Free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH)and human chorionic gonadotropin(HCG)were measured in 837 patients by ACS-180 automatic chemiluninescence analyzer.The Urinary iodine was measured in a random urine by the use of iodine catalytic reaction mechanism of Arsenic-Cerium,rapid urinary iodine using cold digestion method of quantitative detection.Results The median of urine iodine was 224 μg·L-1,ratio of urine iodine ≤100 μg·L-1 was 18.52%,<50 μg·L-1 was 5.26%;The median of urine iodine in the three trimester was 142,147,298 μg·L-1 respectively,and the ratio of low urine iodine in the early gestation and mid-gestation were higher than that in the late gestation(P<0.01).The levels of FT3,FT4 and HCG in the early gestation and mid-gestation were higher than thoes in the late gestation(P<0.05)and TSH was lower than that in the late gestation(P<0.05).FT3,FT4 and HCG levels in high urine iodine group were significantly lower than thoes in low urine iodine group(P<0.05),but there was no significant differences of TSH between the two groups(P>0.05).Conclusion There is no iodine deficiency among pregnant women in Beihai city,but pregnant early,mid-term pregnant women,there is insufficient iodine intake;Hypothyroidism in a mild compensatory state occur in third trimester of pregnancy compared with early and mid-term;Iodine overnutrition may also reduce the levels of thyroid hormones in pregnant women. |
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| Keywords: | urine iodine thyroid hormones iodine nutrition pregnant |
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