| 促甲状腺激素与唾液微生态相关性研究 |
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| 引用本文： | 董婷,罗俊元,黄正蔚. 促甲状腺激素与唾液微生态相关性研究[J]. 四川大学学报(医学版), 2022, 53(2): 226-234. DOI: 10.12182/20220360502 |
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| 作者姓名： | 董婷 罗俊元 黄正蔚 |
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| 作者单位： | 1.上海交通大学医学院附属第九人民医院 牙体牙髓科 （上海 200011） |
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| 基金项目： | 国家自然科学基金（No. 82071104）资助 |
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| 摘 要： | 目的 探讨健康人群唾液微生态组成与其促甲状腺激素（TSH）水平之间的关系。 方法 将纳入的健康人群根据TSH水平分为TSH高组（n=22，TSH 3.00～4.20 mIU/L）和TSH低组（n=24，TSH 0.60～1.80 mIU/L），通过临床和实验室检查对相关的临床和生化指标进行测量分析，并分别对两类人群的唾液样本进行16S rDNA测序和生物信息学分析。 结果 TSH高组和TSH低组的相关临床和生化指标差异并无统计学意义（P>0.05），TSH水平较高的个体的唾液微生物组具有较高的丰度和物种多样性。偏最小二乘判别分析（PLS-DA）显示TSH高组和TSH低组的唾液微生态组β多样性的差异（Adonis，P=0.0460）。Wilcoxon秩和检验和LEFSe分析发现梭杆菌属的丰度在TSH高组和TSH低组间的差异有统计学意义。 结论 健康人群中高TSH和低TSH水平受试者存在不同的唾液微生态组成，其中梭杆菌属在TSH高组和TSH低组中差异最为显著。
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| 关 键 词： | 促甲状腺激素 口腔微生态 16S rDNA测序 |
| 收稿时间： | 2021-10-10 |
Correlational Study of Thyroid-Stimulating Hormone and Salivary Microecology |
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| DONG Ting,LUO Jun-yuan,HUANG Zheng-wei. Correlational Study of Thyroid-Stimulating Hormone and Salivary Microecology[J]. Journal of Sichuan University. Medical science edition, 2022, 53(2): 226-234. DOI: 10.12182/20220360502 |
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| Authors: | DONG Ting LUO Jun-yuan HUANG Zheng-wei |
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| Affiliation: | 1.Department of Endodontics, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China |
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| Abstract: | Objective To investigate the relationship between the composition of salivary microecology and thyroid-stimulating hormone (TSH) levels in healthy adults. Methods Healthy subjects were included in the high-TSH group (n=22, 3.00-4.20 mIU/L) and the low-TSH group (n=24, 0.60-1.80 mIU/L) according to their TSH level. Clinical and laboratory examinations were conducted to measure and analyze the relevant clinical and biochemical indicators. Saliva samples were collected in the two groups and microbial genetic profiles were acquired by 16S rDNA sequencing and bioinformatics analysis. Results There was no significant difference in the relevant clinical and biochemical indicators between the high-TSH group and the low-TSH group (P>0.05). Individuals with higher TSH levels had higher abundance and species diversity of salivary microbiome. Partial least squares discriminant analysis (PLS-DA) found that the microecology of the the high-TSH group and the low-TSH group (Adonis, P=0.0460) showed obvious differences in β diversity. Wilcoxon rank-sum test and LEFSe analysis showed significant difference in the abundance of Fusobacteriumbetween the high-TSH group and the low-TSH group. Conclusion Differences in the composition of microecology were observed in the saliva of healthy subjects with high TSH levels and those with low TSH levels, and the abundance of Fusobacterium showed the most significant difference between the high and low TSH groups. |
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