Microbiome and its impact on gastrointestinal atopy |
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| Authors: | A. B. Muir A. J. Benitez K. Dods J. M. Spergel S. A. Fillon |
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| Affiliation: | 1. Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA;2. Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA;3. Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA;4. University of Colorado School of Medicine, Aurora, CO, USA;5. Digestive Health Institute, Section of Pediatric Gastroenterology, Hepatology and Nutrition, Gastrointestinal Eosinophilic Diseases Program, Mucosal Inflammation Program, Children's Hospital Colorado, Aurora, CO, USA |
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| Abstract: | The prevalence of allergic conditions has continuously increased in the last few decades in Westernized countries. A dysbiotic gut microbiome may play an important role in the development of allergic diseases. Genetic, environmental, and dietary factors may alter the commensal microbiota leading to inflammatory dysregulation of homeostasis. Murine and human studies have begun to elucidate the role of the microbiota in the pathogenesis of atopic diseases including asthma, atopic dermatitis, and food allergies. However, the role of the microbiome in most eosinophilic gastrointestinal diseases (EGIDs) is not yet known. This review provides an overview of what is currently known about the development of tolerance from both molecular and clinical standpoints. We also look at the gut‐specific microbiome and its role in atopic conditions with the hope of applying this knowledge to the understanding, prevention, and treatment of EGIDs, particularly EoE. |
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| Keywords: | asthma atopic dermatitis bacteria eosinophil eosinophilic esophagitis |
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