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The cat lipocalin Fel d 7 and its cross‐reactivity with the dog lipocalin Can f 1 |
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| Authors: | D. Apostolovic S. Sánchez‐Vidaurre K. Waden M. Curin J. Grundström G. Gafvelin T. Cirkovic Velickovic H. Grönlund W. R. Thomas R. Valenta C. Hamsten M. van Hage |
| Affiliation: | 1. Department of Medicine Solna, Immunology and Allergy Unit, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden;2. Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria;3. Department of Clinical Neuroscience, Therapeutic Immune Design Unit, Center for Molecular Medicine (CMM), Karolinska Institutet, Stockholm, Sweden;4. Center of Excellence for Molecular Food Sciences, Faculty of Chemistry, University of Belgrade, Belgrade, Serbia;5. Center for Child Health Research, Telethon Institute of Child Health Research, University of Western Australia, Perth, WA, Australia;6. Center for Inflammatory Diseases, Karolinska Institutet, Stockholm, Sweden |
| Abstract: | We investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat‐sensitized Swedish patients and elucidated its allergenic activity and cross‐reactivity with the dog lipocalin Can f 1. Sixty‐five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross‐reactive antisera. Fel d 7 is a common allergen in a Swedish cat‐sensitized population that cross‐reacts with Can f 1, and may contribute to symptoms in cat‐ but also in dog‐allergic patients. |
| Keywords: | Can f 1 cat allergy cross‐reactivity dog allergy Fel d 7 |