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Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans. |
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| Authors: | M E Klepser E J Wolfe R N Jones C H Nightingale M A Pfaller |
| Abstract: | Time-kill curves were determined for three isolates of Candida albicans tested against fluconazole and amphotericin B at multiples of the MIC. Fluconazole produced fungistatic activity, with concentration-related growth effects observed over a narrow range of concentrations. Amphotericin B exhibited fungicidal activity, with enhancement of activity over a broader range of concentrations. |
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