| 非动脉炎性前部缺血性视神经病变患者的明适应负向波变化特点分析 |
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| 引用本文： | 周歆,任美侠,闵捷,王勇. 非动脉炎性前部缺血性视神经病变患者的明适应负向波变化特点分析[J]. 眼科新进展, 2020, 0(4): 373-376. DOI: 10.13389/j.cnki.rao.2020.0086 |
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| 作者姓名： | 周歆 任美侠 闵捷 王勇 |
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| 作者单位： | 710000 陕西省西安市，西安市第四医院眼科 |
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| 摘 要： | 目的 探讨非动脉炎性前部缺血性视神经病变（non-arterial anterior ischemic optic neuropathy，NAION）患者随病程变化的明适应负向波（photopic negative response，PhNR）变化特点。方法 选取2018年6月至12月就诊于我院的NAION患者18例作为NAION组，另选取正常16人作为正常对照组。根据NAION患者不同视盘水肿状态盘周视网膜神经纤维层（retinal nerve fiber layer，RNFL）厚度的差别，将NAION组进一步分为视盘水肿时的盘周RNFL厚度增加组（以下简称“增加组”）和视盘水肿消退后的盘周RNFL厚度正常及减少组（以下简称“正常及减少组”）。所有受检者均进行PhNR和光学相干断层扫描（optical coherence tomography，OCT）的盘周RNFL厚度检查。结果 NAION组与正常对照组相比，PhNR幅值［分别为（28.23±14.62）μV、（46.24±16.04）μV］显著降低，差异有统计学意义（P=0.00）。增加组、正常及减少组与正常对照组相比，PhNR幅值［（28.77±11.87）μV、（27.96±16.32）μV、（46.24±16.04）μV］均显著降低，差异均有统计学意义（P=0.03、0.00），但增加组和正常及减少组相比，PhNR幅值差异无统计学意义（P=0.92）。增加组PhNR幅值与RNFL厚度呈负相关性（r=-0.86，P=0.03），正常及减少组PhNR幅值与RNFL厚度呈正相关性（r=0.96，P=0.00）。结论 NAION患者发病初期PhNR幅值即显著降低，随着病程进展，PhNR幅值未发生显著变化。NAION视盘水肿时盘周RNFL厚度越大，PhNR幅值越低；视盘水肿消退后盘周RNFL厚度越小，PhNR幅值越低。
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| 关 键 词： | 非动脉炎性前部缺血性视神经病变 明适应负向波 视网膜神经纤维层厚度 |
Characteristic analysis on photopic negative response in patients with non-arterial anterior ischemic optic neuropathy |
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| ZHOU Xin,REN Meixia,MIN Jie,WANG Yong. Characteristic analysis on photopic negative response in patients with non-arterial anterior ischemic optic neuropathy[J]. Recent Advances in Ophthalmology, 2020, 0(4): 373-376. DOI: 10.13389/j.cnki.rao.2020.0086 |
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| Authors: | ZHOU Xin REN Meixia MIN Jie WANG Yong |
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| Affiliation: | Department of Ophthalmology，Xi’an No.4 Hospital，Xi’an 710000，Shaanxi Province，China |
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| Abstract: | Objective To investigate the characteristics of photopic negative response(PhNR)in different courses of non-arterial anterior ischemic optic neuropathy(NAION).Methods Eighteen patients with NAION receiving treatment in our hospital from June to December 2018 were enrolled,and 16 normal subjects were selected.According to different morphologies of optic disc edema and differences in retinal nerve fiber layer(RNFL)thickness around optic disc,patients in NAION group was subdivided into group with increased peridisc RNFL thickness during edema of optic disc(hereinafter referred to“increased group”)and group with normal or decreased peridisc RNFL thickness during edema of optic disc(hereinafter referred to“normal or decreased group”).All subjects received PhNR,measurement of peridisc RNFL thickness by optical coherence tomography(OCT).Results PhNR amplitude in NAION group was(28.23±14.62)nV,which was significantly lower than(46.24±16.04)nV in control group,and statistical difference was observed(P=0.00).PhNR amplitudes were(28.77±11.87)nV in increased group and(27.96±16.32)nV in normal or decreased group,both of which were lower than(46.24±16.04)nV in control group,and the differences were statistically significant(P=0.03,P=0.00),but no difference was observed in PhNR amplitude between increased group and normal or decreased group(P=0.92).There was a negative correlation between PhNR amplitude and RNFL thickness in the increased group(r=-0.86,P=0.03),and a positive correlation between PhNR amplitude and RNFL thickness in the normal or decreased group(r=0.96,P=0.00).Conclusion The PhNR amplitude of NAION patients decreases significantly in the early stage of disease,and it doesn’t change significantly with the progression of disease.The PhNR amplitude decreases with the increase of peridisc RNFL thickness when optic disc has edema.The PhNR amplitude decreases with the reduce of peridisc RNFL thickness when edema is subside. |
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| Keywords: | non-arterial anterior ischemic optic neuropathy photopic negative response retinal nerve fiber layer |
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