|
|||||
|
|
An enzymatic approach to configurationally rare trans‐androsteronyl‐α‐glucoside and Its potential anticancer application |
|
| Authors: | Feng‐Pai Chou Chia‐Tse Tsai Ya‐Sheng Chiou Yi‐Ju Chen Meng‐Erh Li Ting‐Wei Guo Jason WenJay Lyu Sheng‐Hao Chou Tung‐Kung Wu |
| Affiliation: | Department of Biological Science and Technology, National Chiao Tung University, Hsin‐Chu, Taiwan, R.O.C |
| Abstract: | Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl‐α‐glucosides. Investigation of trans‐androsteronyl‐α‐glucoside on tamoxifen‐treated MCF‐7 breast cancer cells shows dose‐dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl‐α‐glucosides with useful biological activities. |
| Keywords: | glycosyltransferase Helicobacter pylori MCF‐7 breast cancer cell steroid α ‐glucoside sterol |