| 异甘草酸镁联合乙酰半胱氨酸治疗药物性肝损伤患者血清氧化应激指标的改变* |
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| 引用本文： | 王红学,朱清静,张玉娟,毛重山. 异甘草酸镁联合乙酰半胱氨酸治疗药物性肝损伤患者血清氧化应激指标的改变*[J]. 实用肝脏病杂志, 2020, 23(2): 227-230. DOI: 10.3969/j.issn.1672-5069.2020.02.020 |
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| 作者姓名： | 王红学 朱清静 张玉娟 毛重山 |
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| 作者单位： | 430040 武汉市 武汉协和东西湖医院感染性疾病科(王红学);门诊部(张玉娟); 武汉市金银潭医院肝病科(朱清静);郑州大学附属河南省人民医院感染性疾病科(毛重山) |
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| 基金项目： | 湖北省科技厅科研基金资助项目(编号:2018312) |
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| 摘 要： | 目的 观察应用异甘草酸镁联合乙酰半胱氨酸治疗药物性肝损伤(DILI)患者血清氧化应激指标的变化。方法 采用随机数字表法将100例DILI患者分为观察组50例和对照组50例。给予对照组异甘草酸镁治疗,给予观察组异甘草酸镁联合乙酰半胱氨酸治疗,两组患者均连续治疗4周。检测血清丙二醛(MDA)、超氧化物岐化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、白介素-6(IL-6)和降钙素原(PCT)。结果 治疗后,观察组血清总胆红素、天冬氨酸氨基转移酶、丙氨酸氨基转移酶和谷氨酰转肽酶水平分别为(14.2±4.6)μmol/L、(62.9±6.8)U/L、(67.5±6.9)、(54.9±8.9)U/L,显著低于对照组【分别为(21.4±7.3)μmol/L、(90.3±8.4)U/L、(86.4±7.5)U/L、(63.6±6.4),P<0.05】;治疗后,观察组血清MDA水平为(4.8±0.7)μmol/L ,显著低于对照组【(6.2±1.1)μmol/L,P<0.05】,血清SOD和GSH-Px水平分别为(81.5±7.9)U/L和(124.7±9.9)U/L,显著高于对照组【分别为(75.5±8.3)U/L和(92.6±8.7)U/L,P<0.05】,血清IL-6和PCT水平分别为(4.2±0.7)pg/L 和(0.3±0.1)ng/L,显著低于对照组【分别为(6.6±1.2)pg/L和(0.5±0.1)ng/L, P<0.05】。结论 联合应用异甘草酸镁和乙酰半胱氨酸治疗DILI患者,近期效果较好,可有效抑制机体炎症反应和氧化应激反应,改善肝功能,值得临床进一步验证。
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| 关 键 词： | 药物性肝损伤 乙酰半胱氨酸 异甘草酸镁 氧化应激 炎症反应 治疗 |
| 收稿时间： | 2019-05-14 |
Efficacy of cetylcysteine combined with magnesium isoglycyrrhizinate in treatment of patients with drug-induced liver injuries |
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| Wang Hongxue,Zhu Qingjing,Zhang Yujuan,et al. Efficacy of cetylcysteine combined with magnesium isoglycyrrhizinate in treatment of patients with drug-induced liver injuries[J]. Journal of Clinical Hepatology, 2020, 23(2): 227-230. DOI: 10.3969/j.issn.1672-5069.2020.02.020 |
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| Authors: | Wang Hongxue Zhu Qingjing Zhang Yujuan et al |
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| Affiliation: | Department of Infectious Diseases, Union and Dongxihu Hospital, Wuhan 430040, Hubei Province, China |
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| Abstract: | Objective The aim of this study was to investigate the efficacy of cetylcysteine combined with magnesium isoglycyrrhizinate in treatment of patients with drug-induced liver injuries(DILI).Methods 100 patients with DILI were randomly divided into observation(n=50)and control group(n=50)in this study.The patients in the control group were treated with magnesium isoglycyrrhizinate,and those in the observation group received acetylcysteine and magnesium isoglycyrrhizinate combination for 4 weeks.Serum malonaldehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),interleukin-6(IL-6)and procalcitonin(PCT)levels were assayed in all the patients.Results At the end on the observation,serum bilirubin,aspartate aminotransferase,alanine aminotransferase and glutamic transpeptidase levels in the combination group were(14.2±4.6)μmol/L,(62.9±6.8)U/L,(67.5±6.9)and(54.9±8.9)U/L,significantly lower than[(21.4±7.3)μmol/L,(90.3±8.4)U/L,(86.4±7.5)U/L and(63.6±6.4),respectively,P<0.05]in the control;serum MDA level was(4.8±0.7)μmol/L,much lower than[(6.2±1.1)μmol/L,P<0.05],serum SOD and GSH-Px levels were(81.5±7.9)U/L and(124.7±9.9)U/L,significantly higher than[(75.5±8.3)U/L and(92.6±8.7)U/L,respectively,P<0.05],serum IL-6 and PCT levels were(4.2±0.7)pg/L and(0.3±0.1)ng/L,significantly lower than[(6.6±1.2)pg/L and(0.5±0.1)ng/L,respectively,P<0.05]in the control.Conclusion The combination of magnesium isoglycyrrhizinate and acetylcysteine in treatment of patients with DILI is efficacious for short-term observation,which might be related to the inhibition of inflammatory reaction and oxidative stress. |
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| Keywords: | Drug-induced liver injury Acetylcysteine Magnesium isoglycyrrhizinate Oxidative stress Inflammatory reaction Therapy |
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