| 白藜芦醇类似物的合成及其抗氧化活性 |
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| 引用本文： | 刘铭,刘伟,蒋杰,程潜,任俊兰. 白藜芦醇类似物的合成及其抗氧化活性[J]. 中国新药杂志, 2011, 0(10) |
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| 作者姓名： | 刘铭 刘伟 蒋杰 程潜 任俊兰 |
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| 作者单位： | 暨南大学药学院新药研究所;广东华南新药创制中心; |
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| 摘 要： | 目的:合成白藜芦醇类似物,以期获得抗氧化活性更好的活性分子。方法:将白藜芦醇的A环分别用活性杂环川芎嗪和4-氨基喹啉替换。考察目标合物9,12及中间体8,11对DPPH自由基的清除作用。结果与结论:设计合成了2个未见文献报道的白藜芦醇类似物,其结构经MS和1H-NMR图谱确证。化合物9,11和12对DPPH自由基的清除作用较白藜芦醇减弱,化合物8在低浓度时具有比白藜芦醇更强的DPPH自由基清除能力,具有潜在的抗氧化作用。
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| 关 键 词： | 白藜芦醇 川芎嗪 4-氨基喹啉 抗氧化活性 |
Synthesis and anti-oxidative activities of resveratrol analogs |
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| LIU Ming,LIU Wei,JIANG Jie,CHENG Qian,REN Jun-lan. Synthesis and anti-oxidative activities of resveratrol analogs[J]. Chinese Journal of New Drugs, 2011, 0(10) |
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| Authors: | LIU Ming LIU Wei JIANG Jie CHENG Qian REN Jun-lan |
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| Affiliation: | LIU Ming1,LIU Wei1,JIANG Jie1,CHENG Qian2,REN Jun-lan2(1 Institute of New Drug Research,Jinan University College of Pharmacy,Guangzhou 510632,China,2 South China Center for Innovative Pharmaceuticals,Guangzhou 510663,China) |
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| Abstract: | Objective: To synthesize the resveratrol analogs with more potent anti-oxidative activities.Methods: The A ring of resveratrol was substituted by TMP ring or 4-aminoquinoline ring.The DPPH radical scavenging abilities of the target molecules 9,12 and intermediate 8,11 were tested.Results and Conclusion: Two novel resveratrol analogues were synthesized,and their structures were confirmed by MS and 1H-NMR.Compoud 8 possesses more potent DPPH radical scavenging ability than resveratrol at low concentration and... |
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| Keywords: | resveratrol ligustrazine 4-aminoquinoline anti-oxidative activity |
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