Early complement components enhance neutralization of Chlamydia trachomatis infectivity by human sera. |
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| Authors: | J S Lin L L Yan Y Ho P A Rice |
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| Affiliation: | Maxwell Finland Laboratory, Boston City Hospital, Massachusetts. |
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| Abstract: | Immunoglobulin G in human serum neutralizes chlamydial infectivity in vitro. Complement-intact, C5-depleted, and C8-depleted human serum all have significantly more neutralizing activity than serum heated to inactivate early components of complement. Cobra venom factor, an analog of human C3b, enhances neutralization of antichlamydial immunoglobulin G in the absence of early complement components. |
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