| 小鼠心梗模型的建立与无创评价 |
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| 引用本文： | 刘建,范慧敏,汪进益,张治国,曹浩,兰琴,史乾,唐光亮,刘中民. 小鼠心梗模型的建立与无创评价[J]. 实验动物与比较医学, 2010, 30(3): 197-200,204. DOI: 10.3969/j.issn.1674-5817.2010.03.010 |
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| 作者姓名： | 刘建 范慧敏 汪进益 张治国 曹浩 兰琴 史乾 唐光亮 刘中民 |
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| 作者单位： | 中国医学科学院/北京协和医学院医学生物学研究所,昆明,650118 |
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| 基金项目： | 国家科技支撑计划项目，云南省科技基础条件平台建设计划项目 |
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| 摘 要： | 目的用高糖高脂饲料＋地塞米松（dexamethasone，DEX）诱导树鼩糖代谢和脂代谢紊乱，为建立实验性2型糖尿病疾病模型提供基础。方法14只雄性中缅树鼩，随机分为高糖高脂组（n=6）和高糖高脂＋DEX组（3mg／kg，h.i.,n=8），连续观察8周，并测定树鼩空腹血糖（FBG）、体重、甘油三酯（TG），总胆固醇（TC），糖化血红蛋白（HA1c）。结果高糖高脂饮食联合地塞米松皮下注射后能够在短时间内使树鼩血糖升高，体重降低，同时发生脂代谢紊乱，糖耐量异常。结论高糖高脂＋地塞米松连续多次空腹注射可诱发树鼩糖代谢、脂代谢紊乱，且动物状态良好。
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| 关 键 词： | 树鼩 糖代谢异常 地塞米松 高糖高脂 |
Establishment and Non-Invasive Assessment of a Mouse Model of Myocardial Infarction |
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| LIU Jian,FAN Hui-min,WANG Jin-yi,ZHANG Zhi-guo,CAO Hao,LAN Qin,SHI Qian,TANG Guang-liang,LIU Zhong-min. Establishment and Non-Invasive Assessment of a Mouse Model of Myocardial Infarction[J]. Laboratory Animal and Comparative Medicine, 2010, 30(3): 197-200,204. DOI: 10.3969/j.issn.1674-5817.2010.03.010 |
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| Authors: | LIU Jian FAN Hui-min WANG Jin-yi ZHANG Zhi-guo CAO Hao LAN Qin SHI Qian TANG Guang-liang LIU Zhong-min |
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| Affiliation: | (Institute of Medical Biology, Chinese Academy of Medical Science, Peking Union Medical College, Kunming 650118, China) |
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| Abstract: | Objective To induce an impaired glucose and lipid metabolism model by high-glucose-fat feeding （HGF） plus DEX so as to facilitate type 2 diabetes study. Methods The model was induced by HGF and HGF plus DEX respectively in tree shrew. Fourteen normal male tree shrews were randomly divided into 2 groups： HGF group with 6 tree shrews and HGF plus DEX group with 8. Several parameters in the tree shrews were measured. Results The fasting blood glucose, lipid level and OGTT significantly increased in HGF~DEX treated group compared with the HGF group while the fasting body weight reduced in both group. Conclusions High-glucose-fat feeding and DEX together can be used to induce glycometabolism and lipid metabolism abnormality. |
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| Keywords: | Tree shrew Impaired glucometabolism Dexamethasone （DEX） High-glucose-fat feeding（HGF） |
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