Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood |
| |
| Authors: | Trudeau Jacqueline D Kelly-Smith Carolyn Verchere C Bruce Elliott John F Dutz Jan P Finegood Diane T Santamaria Pere Tan Rusung |
| |
| Affiliation: | Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada. |
| |
| Abstract: | Autoimmune (type 1) diabetes mellitus results from the destruction of insulin-producing pancreatic beta cells by T lymphocytes. Prediction of cell-mediated autoimmune diseases by direct detection of autoreactive T cells in peripheral blood has proved elusive, in part because of their low frequency and reduced avidity for peptide MHC ligands. This article was published online in advance of the print edition. The date of publication is available from the JCI website, http://www.jci.org. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
