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Differential effect of benserazide (Ro4-4602) on the concentration of indoleamines in rat pineal and hypothalamus. |
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| Authors: | J. Arendt A. K. Ho C. Laud A. Marston V. Nohria J. A. Smith A. M. Symons |
| Abstract: | 1 Low doses (50 and 80 mg/kg) of benserazide (Ro4-4602), an aromatic amino acid decarboxylase inhibitor, markedly reduced 5-hydroxytryptamine and melatonin in the rat pineal gland without affecting hypothalamic 5-hydroxytryptamine. 2 This differential effect shows that inhibition of the pineal gland decarboxylase activity is possible, and confirms that the rat pineal gland is accessible to peripherally acting agents. |
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