| 斯钙素-1在喉癌患者血清中的表达及临床意义 |
| |
| 引用本文： | 赵 宁,谷 佳,李 巍,李笑天,王 琰,郭 星,姜学钧. 斯钙素-1在喉癌患者血清中的表达及临床意义[J]. 现代肿瘤医学, 2015, 0(11): 1508-1511. DOI: 10.3969/j.issn.1672-4992.2015.11.09 |
| |
| 作者姓名： | 赵 宁 谷 佳 李 巍 李笑天 王 琰 郭 星 姜学钧 |
| |
| 作者单位： | 中国医科大学附属第一医院耳鼻咽喉科，辽宁 沈阳 110001 |
| |
| 基金项目： | 国家自然科学基金项目（编号:81102057） |
| |
| 摘 要： | 目的:观察斯钙素-1（STC-1）在喉癌患者和健康人群血清中的表达，探讨STC-1与喉癌患者临床病理特征的关系及对预后判断的指导意义。方法:应用Real time PCR和ELISA方法从基因水平和蛋白水平对喉癌患者及健康人群进行STC-1表达分析，并结合患者病理指标、病理分型和临床随访资料进行回顾性分析。结果:基因水平和蛋白水平检测发现STC-1在喉癌患者血清中表达高于健康对照人群血清中的表达。STC-1表达与病理分化等喉癌血清学指标有一定的相关性，且与喉癌的大小、是否转移及临床分型等密切相关。结论:首次发现STC-1在喉癌血清中高表达，且其表达水平与喉癌的病理分期及不良预后密切相关，是喉癌潜在的诊断预警指标物。
|
| 关 键 词： | TC-1 喉癌 肿瘤标志物 |
STC-1 as a biomarker in laryngeal cancer and the clinical significance |
| |
| Zhao Ning,Gu Jia,Li Wei,Li Xiaotian,Wang Yan,Guo Xing,Jiang Xuejun. STC-1 as a biomarker in laryngeal cancer and the clinical significance[J]. Journal of Modern Oncology, 2015, 0(11): 1508-1511. DOI: 10.3969/j.issn.1672-4992.2015.11.09 |
| |
| Authors: | Zhao Ning Gu Jia Li Wei Li Xiaotian Wang Yan Guo Xing Jiang Xuejun |
| |
| Affiliation: | Department of Otolaryngology，the First Affiliated Hospital of China Medical University，Liaoning Shenyang 110001，China. |
| |
| Abstract: | Objective:To observe the expression of STC-1 in laryngeal cancer patients to explore the clinical and pathological features and its significance on prognostic judgment.Methods:Real time PCR and ELISA methods were used to measure the expression level of STC-1 in laryngeal cancer and the healthy persons.Results:STC-1 was highly expressed in laryngeal cancer than controls，and expression of STC-1 had closed relationship with pathological differentiation，diameters and clinical classification.Conclusion:STC-1 is highly expressed in laryngeal cancer，and its expression level in laryngeal cancer has closed relationship with pathological differentiation and poor prognosis，to be a potential early diagnosis biomarker for laryngeal cancer patients. |
| |
| Keywords: | STC-1 laryngeal cancer tumor biomarker |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《现代肿瘤医学》浏览原始摘要信息 |
|
点击此处可从《现代肿瘤医学》下载免费的PDF全文 |
