| 胃癌手术后替吉奥单药口服化疗的临床疗效 |
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| 引用本文： | 赵卫东1,兰永年1,温小鹏2,刘 磊3,任 宏2. 胃癌手术后替吉奥单药口服化疗的临床疗效[J]. 现代肿瘤医学, 2015, 0(11): 1562-1564. DOI: 10.3969/j.issn.1672-4992.2015.11.26 |
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| 作者姓名： | 赵卫东1 兰永年1 温小鹏2 刘 磊3 任 宏2 |
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| 作者单位： | 1.陕西省扶风县人民医院普外科，陕西 扶风 7222002.西安交通大学第一附属医院胸外2科，陕西 西安 7100613.陕西省富平县人民医院外1科，陕西 富平 711700 |
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| 摘 要： | 目的:观察可手术的胃癌患者术后替吉奥单药的临床应用及其效果。方法:以临床分期Ⅱ期及Ⅲ期胃癌患者，并经手术治疗后获得痊愈者为入选对象，术后1个月试验组给予替吉奥胶囊口服，用量为80mg/（m2·d）,早晚分次口服，d1-14。对照组给于FOLFOX4标准方案，每2周作为一个周期，3周期后评价疗效。结果:试验组与对照组比较:在不良反应发生率、KPS评分级别、临床获益率、有效率、患者手术后2年生存率均无明显统计学差异。结论:胃癌手术后应用替吉奥单药控制，不良反应轻微，术后2年生存率与对照组相比无统计学差异，治疗依从性较好，值得推广应用。
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| 关 键 词： | 替吉奥 胃癌 手术治疗 |
Clinical research of gastric cancer patients treated with single S-1 after operation |
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| Zhao Weidong1,Lan Yongnian1,Wen Xiaopeng2,Liu Lei3,Ren Hong2. Clinical research of gastric cancer patients treated with single S-1 after operation[J]. Journal of Modern Oncology, 2015, 0(11): 1562-1564. DOI: 10.3969/j.issn.1672-4992.2015.11.26 |
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| Authors: | Zhao Weidong1 Lan Yongnian1 Wen Xiaopeng2 Liu Lei3 Ren Hong2 |
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| Affiliation: | 1.Department of General Surgery，People's Hospital of Fufeng County,Shaanxi Fufeng 722200,China;2.Department of Thoracic Surgery，The First Affiliated Hospital,Xi'an Jiaotong University，Shaanxi Xi'an 710061，China；3.Department of Surgery，People's Hospital of Fuping County,Shaanxi Fuping 711700,China. |
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| Abstract: | Objective:To observe clinical application and results of patients with operable gastric cancer treated with S-1 monotherapy.Methods:Clinical stage Ⅱ and Ⅲ patients with gastric cancer，and after surgery to get healed were selected as objects，the test group was given S-1 after one month，with dosage of 80mg/(m2·d)，divided doses in morning and night，day 1-14 medication；Control group was given standard regimen:FOLFOX4，every two weeks as a period.Finally，two groups were evaluated after 3 cycles.Results:In two groups,incidence of adverse reactions，KPS score level，clinical benefit rate，efficient rate，2-year survival rate of patients after surgery，were no significant statistical difference.Conclusion:For gastric cancer patients after surgery with S-1 single drug treatment，adverse reactions are mild，and there were no significant difference between the test group and the control group on 2-year survival rate,and treatment compliance. |
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| Keywords: | S-1 gastric cancer surgical opertion |
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