Breast Cancer and Non‐Hodgkin Lymphoma in a Young Male with Cowden Syndrome |
| |
| Authors: | Robert Tanner Hagelstrom PhD MBA FACMG James Ford MD Gwendolyn M. Reiser MS LCG Marilu Nelson CGCM Diane L. Pickering MS Pamela A. Althof MS CGCM Peter F. Coccia MD |
| |
| Affiliation: | 1. Human Genetics Laboratory, Munroe‐Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska;2. Pediatric Oncology/ Hematology, University of Nebraska Medical Center, Omaha, Nebraska;3. Genetic Medicine, Munroe‐Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska;4. Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska |
| |
| Abstract: | Male breast cancer (MBC) is unusual, especially in young adults. Most cases of MBC as a secondary malignancy relate to the previous treatment with ionizing radiation. MBC can be associated with mutations in hereditary cancer predisposition syndrome genes (i.e., BRCA2); however, no such association has been reported in patients with Cowden syndrome (involving the phosphatase and tensin homolog [PTEN] gene). We describe a patient with Cowden syndrome who was initially diagnosed with B‐cell lymphoblastic lymphoma at the age of 7 years, then MBC at the age of 31 years, and never received radiation therapy. |
| |
| Keywords: | Cowden syndrome B‐cell lymphoblastic lymphoma male breast cancer PTEN |
|
|
