A role for sialoadhesin-positive tissue macrophages in host resistance to lymphoma metastasis in vivo. |
| |
| Authors: | V Umansky, P Beckhove, M Rocha, A Krü ger, P R Crocker, V Schirrmacher |
| |
| Affiliation: | V Umansky, P Beckhove, M Rocha, A Krüger, P R Crocker, and V Schirrmacher |
| |
| Abstract: | Sialoadhesin (SER) is a newly described macrophage-restricted adhesion molecule with a sequence similarity to CD22 on B cells and to myelin-associated glycoprotein on Schwann cells. We describe here a functional role of SER+ spleen macrophages in antigen processing and presentation to T lymphocytes. In two syngeneic murine tumour systems (ESb-MP and lacZ transduced ESbL T-lymphoma cells), the activation state of SER+ macrophages (tested by activity of marker enzymes adenosine deaminase and 5'-nucleotidase) correlated with the arrest of lymphoma metastasis. Furthermore, this macrophage subpopulation became activated upon anti-tumour immunization as well as upon adoptive transfer of immune T lymphocytes into tumour-bearing hosts. We suggest that in situ-activated SER+ macrophages contribute to host resistance against metastasis. |
| |
| Keywords: | |
|
|
