| 黑素瘤免疫治疗的难点及对策 |
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| 引用本文： | 沙姗姗,李军,陶娟. 黑素瘤免疫治疗的难点及对策[J]. 中华皮肤科杂志, 2021, 54(4): 313-317. DOI: 10.35541/cjd.20201111 |
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| 作者姓名： | 沙姗姗 李军 陶娟 |
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| 作者单位： | 1华中科技大学同济医学院附属协和医院皮肤科，武汉430022；2华中科技大学同济医学院附属武汉市中心医院皮肤科430014 |
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| 基金项目： | 国家自然科学基金(81772913、81874135)。 |
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| 摘 要： | 黑素瘤是高度恶性的免疫原性肿瘤，尽管以免疫检查点抑制剂为代表的免疫治疗可显著提高转移性黑素瘤患者的生存率，但仍有近半数患者对免疫治疗产生耐受和抵抗，且免疫相关不良反应发生率高。本文聚焦目前黑素瘤免疫治疗存在的耐受、抵抗及免疫相关不良反应等关键难点，总结相应的对策与研究进展。通过干预黑素瘤免疫抑制性微环境、筛选精准的生物...
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| 关 键 词： | 痣和黑素瘤 免疫疗法 生物制剂 免疫耐受 免疫相关不良反应 生物标记物 |
| 收稿时间： | 2020-11-20 |
Melanoma immunotherapy:difficulties and strategies |
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| Sha Shanshan,Li Jun,Tao Juan. Melanoma immunotherapy:difficulties and strategies[J]. Chinese Journal of Dermatology, 2021, 54(4): 313-317. DOI: 10.35541/cjd.20201111 |
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| Authors: | Sha Shanshan Li Jun Tao Juan |
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| Affiliation: | 1Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; 2Department of Dermatology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China |
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| Abstract: | Melanoma is a highly malignant immunogenic tumor.Although immunotherapy represented by immune checkpoint inhibitors can markedly improve the survival rate of patients with metastatic melanoma,nearly half of patients are still tolerant or resistant to immunotherapy,with high incidence of immune-related adverse reactions.This review focuses on the key difficulties in tolerance,resistance and immune-related adverse reactions to current melanoma immunotherapy,and summarizes corresponding strategies and research advances.By intervening in the immunosuppressive microenvironment in melanoma,screening precise biomarkers,and optimizing immunotherapy-based combination strategies,the problem of tolerance and resistance to immunotherapy can be solved.Moreover,the combination of traditional immunotherapy and nanotechnology can also greatly reduce the occurrence of immune-related adverse reactions.In the future,more extensive and in-depth research on the tumor immune microenvironment will help to explore the best immunotherapy regimens for melanoma. |
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| Keywords: | Nevi and melanomas Immunotherapy Biological agents Immune tolerance Immune-related adverse effects Biomarkers |
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