| 辅助生殖技术在葡萄胎治疗中的应用及研究进展 |
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| 引用本文： | 杨婧祎,刘岩,智旭. 辅助生殖技术在葡萄胎治疗中的应用及研究进展[J]. 国际生殖健康/计划生育杂志, 2021, 40(3): 209-215. DOI: 10.12280/gjszjk.20200612 |
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| 作者姓名： | 杨婧祎 刘岩 智旭 |
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| 作者单位： | 100191 北京大学第三医院妇产科生殖医学中心;100191 北京大学第三医院妇病理科 |
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| 基金项目： | 国家自然科学基金(81671458);国家自然科学基金(81971440);国家重点研发计划“生殖健康及重大出生缺陷防控研究”专项(2018YFC1002302) |
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| 摘 要： | 葡萄胎(hydatidiform mole)是一种临床上较常见的产科疾病,属于妊娠滋养细胞疾病,主要特征是绒毛水肿变性.现阶段葡萄胎的诊断和分类主要通过临床表现和组织学检查.但是,葡萄胎分类复杂且病因不清楚,且复发性葡萄胎再发风险较高,很难预防.随着测序技术的发展,辅助生殖技术,尤其是胚胎植入前遗传学检测,近年来得到了...
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| 关 键 词： | 葡萄胎 妊娠滋养细胞疾病 NLR蛋白质类 生殖技术,辅助 突变 |
| 收稿时间： | 2020-11-04 |
Application of Assisted Reproductive Technology in Hydatidiform Mole |
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| YANG Jing-yi,LIU Yan,ZHI Xu. Application of Assisted Reproductive Technology in Hydatidiform Mole[J]. Journla of International Reproductive Health/Family Planning, 2021, 40(3): 209-215. DOI: 10.12280/gjszjk.20200612 |
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| Authors: | YANG Jing-yi LIU Yan ZHI Xu |
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| Affiliation: | Center for Reproductive Medicine, Department of Obstetrics and Gynecology (YANG Jing-yi, ZHI Xu), Department of Pathology (LIU Yan), Peking University Third Hospital, Beijing 100191, China |
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| Abstract: | Hydatidiform mole (HM) is a common obstetric disease, which is classified as a gestational trophoblastic disease. HM is characterized by swollen villi. HM can be diagnosed and classified by clinical manifestations and histological examination. However, the complex classification and limitations of etiological knowledge of HM, in addition to the high risk of recurrence, make it difficult to prevent. With the development of sequencing technology, the assisted reproductive technology has been rapidly developed in recent years, especially the pre-implantation genetic testing. These technologies can be applied in the acquisition and evaluation of embryos in vitro. However, the application of assisted reproductive technology in HM patients is still confined due to the limitations of current understanding on HM. There are very limited knowledge on the prevention and reproductive guidance of HM, especially the recurrent HM. The epidemiology, clinical manifestations, histology and the genetic characteristics were reviewed in this article, while the application progress of assisted reproductive technology in HM was also discussed. |
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| Keywords: | Hydatidiform mole Gestational trophoblastic disease NLR proteins Reproductive techniques assisted Mutation |
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