| 中性粒细胞胞外诱捕网的形成及其在生殖相关疾病中的作用 |
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| 引用本文： | 乔国栋,王永红. 中性粒细胞胞外诱捕网的形成及其在生殖相关疾病中的作用[J]. 国际生殖健康/计划生育杂志, 2021, 40(3): 260-264. DOI: 10.12280/gjszjk.20200457 |
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| 作者姓名： | 乔国栋 王永红 |
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| 作者单位： | 030001 太原,山西医科大学第二医院妇产科 |
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| 基金项目： | 山西省面上自然基金项目(201901D111367);山西省卫健委科研计划课题(2019050);山西医科大学校级博士启动基金项目(BS201713) |
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| 摘 要： | 中性粒细胞活化后可形成中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs),参与人体内诸多疾病的病理生理过程,但其具体的发病机制尚未阐明.目前研究表明,NADPH氧化酶等细胞因子在其形成过程中发挥重要作用,并通过蛋白酪氨酸激酶(protein tyrosine kinase,P...
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| 关 键 词： | 胞外诱捕网 NADP 蛋白酪氨酸激酶类 p38丝裂原活化蛋白激酶类 丝裂原活化蛋白激酶1 先兆子痫 中性粒细胞胞外诱捕网 |
| 收稿时间： | 2020-07-30 |
Neutrophil Extracellular Traps and Related Reproductive Diseases |
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| QIAO Guo-dong,WANG Yong-hong. Neutrophil Extracellular Traps and Related Reproductive Diseases[J]. Journla of International Reproductive Health/Family Planning, 2021, 40(3): 260-264. DOI: 10.12280/gjszjk.20200457 |
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| Authors: | QIAO Guo-dong WANG Yong-hong |
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| Affiliation: | Department of Obstetrics and Gynecology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China |
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| Abstract: | Neutrophil extracellular traps (NETs) can be formed after the activation of neutrophils, which participate in the pathophysiological process of many diseases including related reproductive diseases. However, the specific pathogenesis has not been clarified. At present, studies have shown that the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and other cytokines play an important role in the formation process of NETs, and that many signaling pathways, such as protein tyrosine kinase (PTK) and phosphatidylinositol 3-kinase (PI3K), regulate the formation of NETs. Many reproductive diseases such as preeclampsia could be further explained by NETs. In this paper, we will review the formation of NETs and the related mechanisms. |
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| Keywords: | Extracellular traps NADP Protein-tyrosine kinases p38 mitogen-activated protein kinases Mitogen-activated protein kinase 1 Pre-eclampsia Neutrophil extracellular traps |
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