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| CDKN2A/2B基因多态性与妊娠糖尿病相关 | |
| 引用本文： | 吕伟东,李萍,张梅,耿厚法,满冬梅,廖更新,班博. CDKN2A/2B基因多态性与妊娠糖尿病相关[J]. 基础医学与临床, 2012, 32(8): 889-893 |
| 作者姓名： | 吕伟东 李萍 张梅 耿厚法 满冬梅 廖更新 班博 |
| 作者单位： | 1. 山东大学医学院,山东济南250012;济宁医学院附属医院内分泌科 2. 济宁医学院附属医院内分泌科 3. 济宁医学院附属医院产科,山东济宁,272029 |
| 基金项目： | 山东省自然科学基金，济宁市科技局课题 |
| 摘 要： | 目的研究CDKN2A/2B基因rs10811661的单核苷酸多态性(SNP),探讨其与妊娠糖尿病(GDM)的相关性。方法选取鲁西南地区正常糖耐量孕妇(NGT)100例、GDM患者120例、2型糖尿病(T2DM)患者100例作为研究对象,提取基因组DNA,采用PCR-RFLP方法检测CDKN2A/2B基因rs10811661多态性。结果 CDKN2A/2B基因rs10811661的TT、TC、CC 3种基因型分布在NGT组与GDM组间有显著差别(P<0.01),GDM组危险等位基因T分布频率显著高于NGT组(P<0.05)。3种基因型及等位基因分布在NGT组与T2DM组之间亦有显著差别(P<0.05)。结论在鲁西南地区女性人群中,CDKN2A/2B基因rs10811661 T/C多态性可能与妊娠糖尿病有明显相关性。 |
| 关 键 词： | 妊娠糖尿病 基因 多态性 CDKN2A/2B |
Correlation of CDKN2A/2B gene single nucleotide polymorphisms with gestational diabetes mellitus |
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| L Wei-dong , LI Ping , ZHANG Mei , GENG Hou-fa , MAN Dong-mei , LIAO Geng-xin , BAN Bo. Correlation of CDKN2A/2B gene single nucleotide polymorphisms with gestational diabetes mellitus[J]. Basic Medical Sciences and Clinics, 2012, 32(8): 889-893 | |
| Authors: | L Wei-dong LI Ping ZHANG Mei GENG Hou-fa MAN Dong-mei LIAO Geng-xin BAN Bo |
| Affiliation: | L(U) Wei-dong , LI Ping , ZHANG Mei , GENG Hou-fa , MAN Dong-mei , LIAO Geng-xin , BAN Bo |
| Abstract: | Objective To investigate the relationship between polymorphisms of rs10811661 in CDKN2A/2B gene and gestational diabetes.Methods The 100 normal glucose tolerance pregnant women,120 gestational diabetes patients and 100 type 2 diabetes patients living in the southwest of Shandong Province were recruited.Using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism,we determined the genotypes of rs10811661 in CDKN2A/2B.Results There was significant difference in genotypic TT,TC and CC frequency of CDKN2A/2B rs10811661 between NGT group and GDM group(P<0.01).The risk allele T frequency in GDM group was significant higher than that in NGT group(P<0.05).So did the difference between NGT group and T2DM group(P<0.05).Conclusions The rs10811661 T/C polymorphisms of CDKN2A/2B gene may be related with the gestational diabetes in the women of the southwest of Shandong Province. |
| Keywords: | gestational diabetes mellitus gene polymorphism CDKN2A/2B |
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