| 基质金属蛋白酶-3和骨桥蛋白在子宫颈癌组织中的表达及其临床意义 |
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| 引用本文： | 刘伟,郑曙民. 基质金属蛋白酶-3和骨桥蛋白在子宫颈癌组织中的表达及其临床意义[J]. 肿瘤研究与临床, 2010, 22(Z1). DOI: 10.3760/cma.j.issn.1006-9801.2010.增.010 |
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| 作者姓名： | 刘伟 郑曙民 |
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| 作者单位： | 1. 山西医科大学研究生处,太原,030001
2. 山西省肿瘤医院妇科 |
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| 摘 要： | 目的 探讨基质金属蛋白酶-3(MMP-3)和骨桥蛋白(OPN)在子宫颈癌组织中的表达及与子宫颈癌浸润转移的关系.方法 采用免疫组织化学SP法检测54例子宫颈癌组织中MMP-3和OPN的表达,并对其与临床病理特征的关系进行分析,以15例正常子宫颈组织为对照.结果 MMP-3和OPN在子宫颈癌组织中的阳性表达率分别为70.37%、66.7%,高于正常子宫颈组织的20%、0;子宫颈间质浸润深度>1/2的阳性表达率显著高于间质浸润深度≤1/2者(P<0.05);子宫颈癌有淋巴结转移者MMP-3和OPN的阳性表达率显著高于无转移者(P<0.05),其表达与浸润深度、淋巴结转移相关.MMP-3与OPN的表达呈显著正相关(r=0.401,P<0.05).结论 MMP-3和OPN与子宫颈癌的浸润转移有关.Abstract：Objective To study the expressions of matrix metalloproteinase-3 (MMP-3) and osteopontin (OPN) in cervical carcinoma and their relationship with invasion and metastasis. Methods The expression of MMP-3 and OPN were detected in 54 cases of cervical cancer tissues by immunohistochemical SP method. Compared with 15 cases of normal cervical tissues, the relationship was analyzed between both protein expressions and clinical pathology. Results The expression positive rates of MMP-3 and OPN in cervical cancer tissues (70.37 % and 66.7 %, respectively) were significantly higher than those of normal cervical tissues (20 % and 0, respectively), were significantly higher with infiltration depth >1/2 and lymph node metastasis than those with depth≤1/2 and without metastasis , respectively(P <0.05). The expressions of MMP-3 and OPN were related with depth of cervical infiltration and lymph node metastasis of cervical cancer.Expressions between MMP-3 and OPN were significantly positively correlation(r =0.401, P<0.05). Conclusion The expressions of MMP-3 and OPN are correlated with invasion and metastasis of cervical carcinoma.
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| 关 键 词： | 子宫颈肿瘤 基质金属蛋白酶-3 骨桥蛋白质 免疫组织化学 |
Expression and clinical significance of matrix metalloproteinase-3 and osteopontin in cervical carcinoma |
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| LIU Wei,ZHENG Shu-min. Expression and clinical significance of matrix metalloproteinase-3 and osteopontin in cervical carcinoma[J]. Cancer Research and Clinic, 2010, 22(Z1). DOI: 10.3760/cma.j.issn.1006-9801.2010.增.010 |
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| Authors: | LIU Wei ZHENG Shu-min |
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| Abstract: | Objective To study the expressions of matrix metalloproteinase-3 (MMP-3) and osteopontin (OPN) in cervical carcinoma and their relationship with invasion and metastasis. Methods The expression of MMP-3 and OPN were detected in 54 cases of cervical cancer tissues by immunohistochemical SP method. Compared with 15 cases of normal cervical tissues, the relationship was analyzed between both protein expressions and clinical pathology. Results The expression positive rates of MMP-3 and OPN in cervical cancer tissues (70.37 % and 66.7 %, respectively) were significantly higher than those of normal cervical tissues (20 % and 0, respectively), were significantly higher with infiltration depth >1/2 and lymph node metastasis than those with depth≤1/2 and without metastasis , respectively(P <0.05). The expressions of MMP-3 and OPN were related with depth of cervical infiltration and lymph node metastasis of cervical cancer.Expressions between MMP-3 and OPN were significantly positively correlation(r =0.401, P<0.05). Conclusion The expressions of MMP-3 and OPN are correlated with invasion and metastasis of cervical carcinoma. |
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| Keywords: | Uterine cervical neoplasms Matrix metalloproteinase-3 Osteopontin Immunohistochemistry |
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