| 骨桥蛋白在子宫颈鳞癌患者局部组织中的表达 |
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| 引用本文： | 孙晓玲,姚卫红,卫庆萍,付亚红,冯锋. 骨桥蛋白在子宫颈鳞癌患者局部组织中的表达[J]. 肿瘤研究与临床, 2010, 22(Z1). DOI: 10.3760/cma.j.issn.1006-9801.2010.增.004 |
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| 作者姓名： | 孙晓玲 姚卫红 卫庆萍 付亚红 冯锋 |
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| 作者单位： | 1. 长治市人民医院妇科,046000
2. 长治市人民医院病理科,046000 |
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| 摘 要： | 目的 检测骨桥蛋白(OPN)在慢性子宫颈炎、子宫颈上皮内瘤变(CIN)、子宫颈鳞癌患者相应子宫颈局部组织中的表达水平,探讨OPN作为子宫颈鳞癌标志物的可能性.方法 应用免疫组织化学(SP法)检测25例慢性子宫颈炎、18例CIN和21例子宫颈鳞癌患者子宫颈局部组织中OPN的表达.结果 OPN在慢性子宫颈炎、CIN和子宫颈鳞癌的阳性表达率分别是48%、77.78%和80.95%,依次呈上升趋势,且差异有统计学意义(P<0.05).子宫颈鳞癌组织中OPN的表达水平与患者年龄、肿瘤大小、临床分期等临床病理特征相关性均无统计学意义(P>0.05).子宫颈鳞癌患者OPN表达与肿瘤的临床分期无关,但结果 显示随着临床分期的逐渐升高.OPN表达阳性率逐渐升高.结论 OPN在子宫颈鳞癌组织中呈高表达,其表达水平可能与子宫颈鳞癌的发生、发展有关.Abstract：Objective To detect the expression of osteopontin (OPN) in cervical local tissues of patients with chronic cervicitis, cervical intraepithelial neoplasia (CIN), cervical cancer. To investigate the possibility that OPN is used as tumor marker of cervical cancer. Methods The expression of OPN in 25 cases of chronic cervicitis, 18 cases of CIN and 21 cases of cervical cancer was detected by immuohistochemistry SP method. Results The positive expression rates of OPN in the chronic cervicitis, CIN and the cervical cancer had a rising trend (48 %, 77.78 % and 80.95 %, respectively) and their differences had statistical significant (P <0.05). The OPN expression level in cervical cancer had no statistical correlation with age, tumor size, clinical stage and other clinical pathological features (P >0.05). Although OPN expression level in cervical cancer wasn' t related with tumor clinical stage, positive expression rates of OPN had a gradually increased trend along with the clinical stage. Conclusion High expression of OPN is found in cervical cancer and may be related to the occurrence and development of cervical cancer.
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| 关 键 词： | 骨桥蛋白 慢性子宫颈炎 子宫颈上皮内瘤变 子宫颈鳞癌 |
Expression of osteopontin in local tissues of patients with cervical cancer |
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| SUN Xiao-ling,YAO Wei-hong,WEI Qing-ping,FU Ya-hong,FENG Feng. Expression of osteopontin in local tissues of patients with cervical cancer[J]. Cancer Research and Clinic, 2010, 22(Z1). DOI: 10.3760/cma.j.issn.1006-9801.2010.增.004 |
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| Authors: | SUN Xiao-ling YAO Wei-hong WEI Qing-ping FU Ya-hong FENG Feng |
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| Abstract: | Objective To detect the expression of osteopontin (OPN) in cervical local tissues of patients with chronic cervicitis, cervical intraepithelial neoplasia (CIN), cervical cancer. To investigate the possibility that OPN is used as tumor marker of cervical cancer. Methods The expression of OPN in 25 cases of chronic cervicitis, 18 cases of CIN and 21 cases of cervical cancer was detected by immuohistochemistry SP method. Results The positive expression rates of OPN in the chronic cervicitis, CIN and the cervical cancer had a rising trend (48 %, 77.78 % and 80.95 %, respectively) and their differences had statistical significant (P <0.05). The OPN expression level in cervical cancer had no statistical correlation with age, tumor size, clinical stage and other clinical pathological features (P >0.05). Although OPN expression level in cervical cancer wasn' t related with tumor clinical stage, positive expression rates of OPN had a gradually increased trend along with the clinical stage. Conclusion High expression of OPN is found in cervical cancer and may be related to the occurrence and development of cervical cancer. |
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| Keywords: | Osteopontin Chronic cervicitis Cervical intraepithelial neoplasia Cervical cancer |
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