| 大鼠主动脉球囊成形术后尾加压素II受体的变化 |
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| 引用本文： | 夏春芳,徐少平,张勇刚,杨军,霍勇,庞永正,唐朝枢. 大鼠主动脉球囊成形术后尾加压素II受体的变化[J]. 中国病理生理杂志, 2001, 0(7) |
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| 作者姓名： | 夏春芳 徐少平 张勇刚 杨军 霍勇 庞永正 唐朝枢 |
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| 基金项目： | 国家九五医学攻关项目 (No .96 - 90 6 0 2 - 0 7)，国家自然科学基金资助项目 (No .39730 2 2 0 ) |
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| 摘 要： | 目的 :观察大鼠主动脉球囊成形术后尾加压素II (UII)受体特征的变化及血管对UII收缩效应的改变。方法 :测定大鼠主动脉球囊损伤后 [12 5I]-UII配体结合及血管张力。结果 :球囊成形术后 3d、2 1d时 ,血管对UII的反应性增强 (P <0 0 5 ) ,主动脉UII受体最大结合 (Bmax)较对照组分别高 44 %及 36 % [(35 0 3± 2 41)pmol/gproteinand (33 2 6± 2 40 )pmol/gproteinvs(2 4 37± 3 2 0 )pmol/gprotein ,P <0 0 1],受体与配体解离常数 (Kd)无显著差异 (P >0 0 5 )。结论 :血管球囊损伤后UII受体发生上调 ,受体密度增加 ,血管对UII的反应性增强 ,表明UII可能在血管成形术后再狭窄过程中发挥重要作用。
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| 关 键 词： | 尿紧张素类 受体 内源性物质 血管成形术 气囊 大鼠 主动脉 |
The alteration of urotensin-II receptors in rat aorta after balloon angioplasty injury |
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| XIA Chun-fang ,XU Shao-ping ,ZHANG Yong-gang ,YANG Jun ,HUO Yong ,PANG Yong-zheng ,TANG Chao-shu. The alteration of urotensin-II receptors in rat aorta after balloon angioplasty injury[J]. Chinese Journal of Pathophysiology, 2001, 0(7) |
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| Authors: | XIA Chun-fang XU Shao-ping ZHANG Yong-gang YANG Jun HUO Yong PANG Yong-zheng TANG Chao-shu |
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| Affiliation: | XIA Chun-fang 1,XU Shao-ping 2,ZHANG Yong-gang 1,YANG Jun 1,HUO Yong 1,PANG Yong-zheng 1,TANG Chao-shu 1 |
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| Abstract: | AIM: To observe the alteration of urotensin II (UII) receptors and contractile response to UII in rat aorta after balloon angioplasty injury. METHODS: The plasma membrane isolated from balloon injured aorta was used to study the binding of [ 125 I]-UII to the membrane and the contractile potency of UII on rat aorta was assayed. RESULTS: In contrast to the normal aorta, the contractile potency to UII enhanced in balloon injury artery and the calculated maximal number of specific binding sites (Bmax) was increased about 44% and 36% respectively in rat artery after balloon injury 3 and 21 days ( P< 0.01). CONCLUSION: The density of UII receptors and the contractile response to UII had changed after balloon angioplasty injury. It was proposed that UII might play an important role in the intervention of restenosis after angioplasty. [ |
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| Keywords: | Urotensins Receptor endogenous substances Angioplasty balloon Rats Aorta |
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