| 干细胞在特发性肺纤维化治疗中的研究与应用综述 |
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| 引用本文： | 冯小蓉,尧捷,吴涯,程霞,邹坪金,王华,杨牧. 干细胞在特发性肺纤维化治疗中的研究与应用综述[J]. 四川大学学报(医学版), 2021, 52(3): 373-379. DOI: 10.12182/20210560304 |
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| 作者姓名： | 冯小蓉 尧捷 吴涯 程霞 邹坪金 王华 杨牧 |
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| 作者单位： | 电子科技大学医学院附属肿瘤医院肿瘤基础转化研究中心 ,成都 610041;电子科技大学医学院 ,成都 610041;电子科技大学医学院附属肿瘤医院肿瘤基础转化研究中心 ,成都 610041 |
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| 基金项目： | 中国科技部重点研发计划（No. 2018YFA0108604）和四川省国际科技创新/港澳台科技创新合作重点项目（No. 2020YFH0167）资助 |
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| 摘 要： | 特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一类呈急性或慢性进展的不可逆肺部疾病,最终会导致患者肺功能严重损害乃至死亡.目前,肺纤维化的发病机理尚不明确,无有效的治疗手段延缓病情进展.研究显示,干细胞作为机体的起源细胞,不仅参与机体各阶段的发育,在肺损伤修复方面也发挥重要作用....
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| 关 键 词： | 特发性肺纤维化 干细胞移植治疗 定向分化 组织微环境 |
| 收稿时间： | 2021-01-08 |
Research and Application of Stem Cell-Based Therapy in Idiopathic Pulmonary Fibrosis: A Review |
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| FENG Xiao-rong,YAO Jie,WU Ya,CHENG Xia,ZOU Ping-jin,WANG Hua,YANG Mu. Research and Application of Stem Cell-Based Therapy in Idiopathic Pulmonary Fibrosis: A Review[J]. Journal of Sichuan University. Medical science edition, 2021, 52(3): 373-379. DOI: 10.12182/20210560304 |
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| Authors: | FENG Xiao-rong YAO Jie WU Ya CHENG Xia ZOU Ping-jin WANG Hua YANG Mu |
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| Affiliation: | 1.Centre for Basic and Translational Research in Cancer, Sichuan Cancer Hospital & Institute, University of Electronic Science and Technology of China, Chengdu 610041, China |
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| Abstract: | Idiopathic pulmonary fibrosis (IPF) is a type of pulmonary disease that progresses acutely or slowly into irreversible pulmonary diseases, resulting in the end severe damages to patients' lung functions, as well as deaths. At present, the pathogenesis of pulmonary fibrosis is still not clear and there is no effective therapeutic measure available to control the progression of the disease. Research findings indicate that stem cells, being the origin of all cells of organisms, participate in the development of individuals at various stages and play an important role in repairing pulmonary tissue damage. Stem cells are attracting growing attention in the field of regenerative medicine, providing new ideas for treating IPF with transplanted stem cells. Herein, in order to better explore the potential applications of stem cell transplantation in treating IPF, we attempt to summarize preliminary studies of stem cell-mediated pulmonary remodeling after IPF, as well as cutting-edge clinical trials in stem cell-based IPF therapy. |
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