| 不同分期慢性肾脏病患者骨质疏松与心血管钙化的横断面调查 |
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| 引用本文： | 蔡志岳,胡显芳,陈利群,李正荣,杜晓刚. 不同分期慢性肾脏病患者骨质疏松与心血管钙化的横断面调查[J]. 四川大学学报(医学版), 2021, 52(2): 334-339. DOI: 10.12182/20210360507 |
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| 作者姓名： | 蔡志岳 胡显芳 陈利群 李正荣 杜晓刚 |
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| 作者单位： | 重庆医科大学附属第一医院肾内科 重庆 400042 |
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| 基金项目： | 重庆市自然科学基金面上项目（No. cstc2019jcyj-msxmX0504）资助 |
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| 摘 要： | 目的 了解不同分期慢性肾脏病(CKD)患者骨质疏松与心血管钙化的情况,分析其与骨代谢标志物之间的相关性.方法 选择2017年7月?2018年1月就诊于重庆医科大学附属第一医院和重庆市涪陵中心医院的368例CKD 3～5期患者,另选60例同期于本院和重庆市涪陵中心医院体检的健康者为对照组.收集所有研究对象入组时的年龄、性...
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| 关 键 词： | 骨代谢标志物 估算肾小球滤过率 慢性肾脏病 矿物质和骨代谢异常 |
| 收稿时间： | 2020-01-02 |
A Cross-sectional Study of Osteoporosis and Cardiovascular Calcification in Patients with Chronic Kidney Disease at Different CKD Stages |
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| CAI Zhi-yue,HU Xian-fang,CHEN Li-qun,LI Zheng-rong,DU Xiao-gang. A Cross-sectional Study of Osteoporosis and Cardiovascular Calcification in Patients with Chronic Kidney Disease at Different CKD Stages[J]. Journal of Sichuan University. Medical science edition, 2021, 52(2): 334-339. DOI: 10.12182/20210360507 |
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| Authors: | CAI Zhi-yue HU Xian-fang CHEN Li-qun LI Zheng-rong DU Xiao-gang |
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| Affiliation: | Department of Nephrology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China |
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| Abstract: | Objective To investigate the status of osteoporosis and cardiovascular calcification in patients with chronic kidney disease (CKD) with different stages, and analyze the correlation between the stages and markers of bone metabolism To correlation. Methods A total of 368 CKD patients at stage 3-5 who were treated in First Affiliated Hospital Affiliate to Chongqing Medical University and Chongqing Fuling Central Hospital from July 2017 to January 2018 were enrolled. A total of 60 healthy people who underwent physical examination in the hospital during the same period were enrolled as control group. Age, gender and body mass index (BMI) of all study objects at enrollment time were collected. The levels of estimate glomerular filtration rate (eGFR), serum calcium (Ca), phosphorus (P), albumin (ALB), intact parathyroid hormone (iPTH), bone alkaline phosphatase (BALP), procollagen Ⅰ N-terminal peptide (PINP) and β-crosslaps (β-CTX) were detected. The occurrence of osteoporosis, vascular calcification and heart valve calcification was detected. Pearson correlation analysis was applied to analyze correlation between eGFR, serum bone metabolism markers and osteoporosis, cardiovascular calcification. Results Compared with control group, levels of serum P, iPTH, BALP, PINP and β-CTX were significantly increased in CKD stage 3-5 group (P<0.05), while levels of eGFR and serum Ca were decreased (P<0.05). With the increase of CKD staging, changes of their levels were more significant (P<0.05). The incidence of vascular calcification and heart valve calcification in CKD stage 5 hemodialysis group was higher than that in CKD stage 3-4 group and CKD stage 5 without dialysis group (P<0.05). eGFR was positively correlated with serum Ca in CKD patients at stage 3-5 (P<0.05), while negatively correlated with serum P, iPTH, BALP, PINP and β-CTX (P<0.05). The occurrence of osteoporosis, vascular calcification and heart valve calcification was negatively correlated with increase of eGFR and serum Ca levels in CKD patients at stage 3-5 (P<0.05), while positively correlated with increase of levels of serum P, iPTH, BALP, PINP and β-CTX (P<0.05). Conclusion The levels of serum bone metabolism markers and eGFR are closely related to occurrence of osteoporosis and cardiovascular calcification in CKD patients at stage 3-5. |
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