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| 卵巢上皮性肿瘤中PTEN和Survivin的表达及意义 | |
| 引用本文： | 朱巧英,沈宇飞,胡建铭,詹升华. 卵巢上皮性肿瘤中PTEN和Survivin的表达及意义[J]. 实用医学杂志, 2009, 25(18) |
| 作者姓名： | 朱巧英 沈宇飞 胡建铭 詹升华 |
| 作者单位： | 1. 南京医科大学附属南京市妇幼保健院妇科,210004 2. 苏州大学附属第一医院妇产科,215006 3. 苏州大学附属第一医院病理科,215006 |
| 摘 要： | [摘 要] 目的: 研究卵巢上皮性肿瘤中PTEN和Survivin的表达。方法: 采用免疫组织化学法用PTEN和Survivin特异性抗体检测PTEN和Survivin在57例卵巢上皮性癌、20例卵巢良性上皮性肿瘤和10例正常卵巢组织标本中的表达。结果: (1) 卵巢上皮性癌中Survivin的阳性表达率（64.91%）明显高于正常卵巢组织中的表达率（0%）及卵巢良性上皮性瘤中的表达率（0%）(Ｐ<0.01), Survivin在卵巢上皮性癌中的过度表达率为52.63%；（2）卵巢上皮性癌中PTEN的阳性表达率（38.60%）明显低于正常卵巢组织的表达率（100%）及卵巢良性上皮性瘤中的表达率（95.00%）(Ｐ<0.05)；（3）Survivin的阳性表达、PTEN的阴性表达及Survivin阳性与PTEN阴性的共表达与卵巢上皮性癌的临床分期、病理分级正相关(Ｐ<0.05)。结论:（1）Survivin的表达上调及PTEN的表达下调与卵巢上皮性癌的发生相关，并且在卵巢上皮性癌的发生发展中有协同作用，联合检测其中的指标对于评价卵巢上皮性癌的恶性程度、转移及预后具有临床价值。（2）用PTEN对卵巢上皮性癌进行基因治疗或对卵巢上皮性癌进行针对Survivin的基因治疗及靶向性药物治疗有一定的可能性。 |
| 关 键 词： | 卵巢肿瘤 PTEN Survivin 共表达 |
| 收稿时间： | 2009-02-12 |
Expression of PTEN and survivin in ovarian epithelial neoplasms |
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| ZHU Qiao-ying,SHEN Yu-fei,HU Jian-ming,ZHAN Sheng-hua. Expression of PTEN and survivin in ovarian epithelial neoplasms[J]. The Journal of Practical Medicine, 2009, 25(18) | |
| Authors: | ZHU Qiao-ying SHEN Yu-fei HU Jian-ming ZHAN Sheng-hua |
| Abstract: | [Abstract] Objective To investigate the expression of PTEN and survivin in ovarian epithelial neoplasms. Patients and Methods The PTEN protein and survivin protein was detected in 57 samples of ovarian epithelial carcinomas,20 samples of benign ovarian epithelial tumors and 10 normal ovarian issues using PTEN and survivin specific antibody by immunohistochemistry.57 samples of ovarian epithelial carcinomas include 20 cases of Ⅰ～Ⅱ stage and 37 cases of Ⅲ～Ⅳ stage ;27 cases of G1, 8 cases of G2 and 22 cases of G3. Results (1) Survivin immunoreaction was observed in 37/57(64.91%) cases of ovarian epithelial carcinomas,but not in benign ovarian epithelial tumors and normal ovarian issues. 52.63% of ovarian epithelial carcinomas present overexpression of Survivin . The percentage of Survivin positivity was significantly higher in ovarian epithelial carcinoma than benign ovarian epithelial tumors and normal ovarian issues (P < 0.01) .(2) the positive expression of PTEN was significantly lower in ovarian epithelial carcinomas than in benign ovarian epithelial tumors and normal ovary issues(Ｐ<0.05).(3) Statistically significant higher percentage of PTEN negative and Survivin positivity were found in I to II stages than in III to IV stages(Ｐ<0.05,Ｐ<0.01 ,respectively),and same status exist between low grade and high grade（Ｐ<0.01,Ｐ<0.05, respectively）. the level of the co-expression of PTEN negative with Survivin positive had positive correlations with clinical stages and histological grades too(Ｐ<0.05). CONCLUSIONS (1) Up-regulation of Survivin expression with down- regulation of PTEN expression might play an important role in the oncogenesis of ovarian epithelial carcinomas. PTEN and Survivin have synergistic action related to the oncogensis and progression. To detect these molecules simultaneously, we can better evaluate the malignancy,metastasise and prognosis of ovarian epithelial carcinoma.(2) we could target on PTEN to perform gene therapy of ovarian epithelial carcinoma. overexpression of Survivin shows therapeutic targeting of survivin in ovarian carcinoma is a future possibility. |
| Keywords: | PTEN Survivin |
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