|
|||||
|
|
| 血管内皮生长因子、增殖细胞核抗原在肝癌组织中的表达及其意义 | |
| 引用本文： | 史冬,陈彩云,夏宗江,李印. 血管内皮生长因子、增殖细胞核抗原在肝癌组织中的表达及其意义[J]. 实用医学杂志, 2009, 25(1): 76-77 |
| 作者姓名： | 史冬 陈彩云 夏宗江 李印 |
| 作者单位： | 1. 河南省南阳市第三人民医院内科,473000 2. 郑州大学第一附属医院普外科,450001 3. 河南省南阳市中心医院病理科,473000 |
| 摘 要： | 目的:探讨血管内皮生长因子(VEGF)、增殖细胞核抗原(PCNA)在原发性肝癌中的表达及其意义。方法:采用免疫组化SP法检测了60例原发性肝癌组织中VEGF、PCNA的表达。结果:60例原发性肝癌的VEGF阳性表达率(71.7%)明显高于正常对照组(30.0%)(P<0.05)。但临床Ⅲ～Ⅳ期的表达率(80.0%)与Ⅰ～Ⅱ期的表达率(63.3%)无统计学差异(P>0.05)。PCNA在原发性肝癌中阳性表达率(60.0%)明显高于正常对照组(20.0%)(P<0.05),但临床Ⅲ～Ⅳ期的表达率(66.7%)与Ⅰ～Ⅱ期的表达率(53.3%)之间无统计学差异(P>0.05)。结论:VEGF和PCNA可以作为评价原发性肝癌预后的重要指标。 |
| 关 键 词： | 肝肿瘤 血管内皮生长因子A 增殖细胞核抗原 免疫组织化学 |
| 收稿时间： | 2008-05-28 |
Expression and clinical significances of Vascular Endothelial Growth Factor and Proliferating Cell Nuclear Antigen In hepatocellular carcinoma |
|
| Abstract: | Abstract: Objective:To investigate the function of vascular endothelial growth factor(VEGF) and proliferating cell nuclear antigen(PCNA) in hepatocellular carcinoma(HCC) tissues. Methods: The expression of VEGF and PCNA was evaluated in 60 specimens of hepatocellular carcinoma by immunohistochemistry S-P method. Results: the positive rate of VEGF was 71.7%. It has significant difference between normal tissue and hepatocellular carcinoma(P<0.05), but no statistically significant difference was found between clinical stage Ⅰ-Ⅱ and clinical stage Ⅲ-Ⅳ(P>0.05). The positive rate of PCNA was 60% in hepatocellular carcinoma. It has significant difference between normal tissue and hepatocellular carcinoma(P<0.05), but no statistically significant difference was found between clinical stage Ⅰ-Ⅱ and clinical stage Ⅲ-Ⅳ(P>0.05). Conclusion: VEGF and PCNA may serve as a parameter for predicting recurrence, metastasis and prognosis of hepatocellular carcinoma. |
| Keywords: | |
| 本文献已被 维普 万方数据 等数据库收录！ | |
| 点击此处可从《实用医学杂志》浏览原始摘要信息 | |
| 点击此处可从《实用医学杂志》下载全文 | |