|
|||||
|
|
Impact of 1, 25-(OH)2D3 on Left Ventricular Hypertrophy in Type 2 Diabetic Rats |
|
| Authors: | Ying Fan Shan-xiao Zhang Meng Ren Li-feng Hong Xiao-ni Yan |
| Affiliation: | 1Department of Cardiology, the Fifth Hospital of Wuhan & Institute of Cardiovascular Sciences of Jianghan University, Wuhan 430050, China; 2Department of Cardiology, the First Hospital of Yangtze University,Jingzhou, Hubei 434000, China |
| Abstract: | Objective To investigate the impact of 1, 25-(OH)2D3 on left ventricular hypertrophy (LVH) in type 2 diabetic rats. Methods Type 2 diabetic mellitus (DM) model rats were established by intraperitoneally injecting with 30 mg/kg streptozotocin. After 8 weeks, 19 male rats were identified as diabetic with left ventricular hypertrophy (LVH) by ultrasound examination, and randomly assigned into three groups:untreated (DM-LVH, n=7), treated with insulin (DM-LVH+INS, n=6), and treated with 1, 25-(OH)2D3 (DM-LVH+VD, n=6). Healthy male rats were used as the controls group (n=6). The fasting blood glucose and the insulin level were determined weekly. The left ventricular mass index, myocardial collagen content, collagen volume fraction, and 1, 25-(OH)2D3-receptor level were determined by 4 weeks later. Results In the DM-LVH model group, the insulin level was significantly decreased compared with the non-diabetic control group (P<0.05), whereas the blood glucose, left ventricular mass index, myocardial collagen content, collagen volume fraction, and 1, 25-(OH)2D3-receptor expression were significantly increased (all P<0.05). In the DM-LVH+INS and DM-LVH+VD groups, the insulin levels were significantly increased compared with the DM-LVH model group (P<0.05), whereas the other parameters were significantly decreased (all P<0.05). Conclusion 1, 25-(OH)2D3 could reverse LVH in diabetic rats and that the mechanism may involve stimulating insulin secretion and reducing blood glucose via direct up-regulation of 1, 25-(OH)2D3-receptor expression. |
| Keywords: | 1,25-(OH)2D3 left ventricular hypertrophy type 2 diabetes mellitus rat |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
| 点击此处可从《中国医学科学杂志(英文版)》浏览原始摘要信息 | |
| 点击此处可从《中国医学科学杂志(英文版)》下载全文 | |