Serum brain‐derived neurotrophic factor and interleukin‐6 response to high‐volume mechanically demanding exercise |
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| Authors: | Vaidas Verbickas MS Sigitas Kamandulis PhD Audrius Snieckus PhD Tomas Venckunas PhD Neringa Baranauskiene PhD Marius Brazaitis PhD Danguole Satkunskiene PhD Alvydas Unikauskas PhD Albertas Skurvydas PhD |
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| Affiliation: | 1. Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, Lithuania, Sporto 6, LT 44221, Kaunas, Lithuania;2. Department of Laboratory Medicine, Medical Academy, Lithuanian University of Health Sciences, Mickeviciaus 9, Kaunas, Lithuania |
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| Abstract: | Introduction: The aim of this study was to follow circulating brain‐derived neurotrophic factor (BDNF) and interleukin‐6 (IL‐6) levels in response to severe muscle‐damaging exercise. Methods: Young healthy men (N = 10) performed a bout of mechanically demanding stretch–shortening cycle exercise consisting of 200 drop jumps. Voluntary and electrically induced knee extension torque, serum BDNF levels, and IL‐6 levels were measured before and for up to 7 days after exercise. Results: Muscle force decreased by up to 40% and did not recover by 24 hours after exercise. Serum BDNF was decreased 1 hour and 24 hours after exercise, whereas IL‐6 increased immediately and 1 hour after but recovered to baseline by 24 hours after exercise. IL‐6 and 100‐Hz stimulation torque were correlated (r = ?0.64, P < 0.05) 24 hours after exercise. Discussion: In response to acute, severe muscle‐damaging exercise, serum BDNF levels decrease, whereas IL‐6 levels increase and are associated with peripheral fatigue. Muscle Nerve 57 : E46–E51, 2018 |
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| Keywords: | central motor fatigue cytokines muscle soreness muscle torque peripheral fatigue stretch‐shortening cycle exercise |
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