Disposition and metabolic profiles of [14C]viramidine and [14C]ribavirin in rat and monkey red blood cells and liver |
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| Authors: | Lin Chin-Chung Lourenco David Xu Guifen Yeh Li-Tain |
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| Affiliation: | Research and Development, Valeant Pharmaceuticals International, Costa Mesa, California 92626, USA. cclin@valeant.com |
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| Abstract: | The disposition and metabolic profiles of [14C]viramidine and [14C]ribavirin were compared in rat and monkey red blood cells and liver. Our data reveal that the total ribavirin-related components (ribavirin plus its mono-, di-, and triphosphate metabolites) may account for most of the drug in monkey liver following prolonged oral administration of viramidine. |
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