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Paradoxical immune reconstitution inflammatory syndrome associated with disseminated tuberculosis infection in an unrelated donor cord blood transplant recipient |
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| Authors: | Yeon Joo Lee Melissa Bacchus Elizabeth Schmidt Mohit Chawla Juliet N. Barker Genovefa A. Papanicolaou |
| Affiliation: | 1. Department of Medicine, Infectious Diseases Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA;2. Weill Cornell Medical College, New York, NY, USA;3. Department of Medicine, Pulmonary Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA;4. Department of Medicine, Adult Bone Marrow Transplantation Services, Memorial Sloan Kettering Cancer Center, New York, NY, USA |
| Abstract: | Tuberculosis (TB) is an infrequent infection after hematopoietic cell transplant (HCT), with associated mortality up to 30%. The utility of universal screening for latent TB in HCT candidates is controversial due to the lack of sensitive screening tests. We describe a case of disseminated TB infection complicated by immune reconstitution inflammatory syndrome in an adult double unit umbilical cord blood transplant recipient who originated from the United Arab Emirates. |
| Keywords: | hematopoietic cell transplant immune reconstitution inflammatory syndrome tuberculosis |