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Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3‐like 1 and neurofilament light chain
Authors:E. Quintana  C. Coll  J. Salavedra‐Pont  M. Muñoz‐San Martín  R. Robles‐Cedeño  J. Tomàs‐Roig  M. Buxó  C. Matute‐Blanch  L. M. Villar  X. Montalban  M. Comabella  H. Perkal  J. Gich  L. Ramió‐Torrentà
Affiliation:1. Neuroimmunology and Multiple Sclerosis Unit [Girona Biomedical Research Institute] IDIBGI, Neurology Department, Dr. Josep Trueta University Hospital, Girona, Spain;2. Red Espa?ola de Esclerosis Múltiple (REEM), Madrid;3. Medical Sciences Department, Faculty of Medicine, University of Girona, Girona;4. Girona Biomedical Research Institute (IDIBGI), Girona;5. Servei de Neurologia–Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona;6. Immunology Department, IRYCIS, Hospital Ramón y Cajal, Madrid, Spain;7. Medical Sciences Department, Faculty of Medicine, University of Girona, GironaThese authors contributed equally as principal investigators.
Abstract:
Keywords:biomarkers  chitinase 3‐like 1  mild cognitive impairment  multiple sclerosis  neurofilament light chain
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