| 氟伏沙明对癌症后抑郁患者血清褪黑素的影响 |
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| 引用本文： | 杨清,杨绍峰,张璐璐,毕晓伟,张艳,王梅,史风磊. 氟伏沙明对癌症后抑郁患者血清褪黑素的影响[J]. 中国临床保健杂志, 2017, 20(6): 676-678 |
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| 作者姓名： | 杨清 杨绍峰 张璐璐 毕晓伟 张艳 王梅 史风磊 |
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| 作者单位： | 1.山东青岛市市立医院药剂科;2.山东青岛市市立医院肿瘤科 |
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| 基金项目： | 山东省自然科学基金项目(ZR2015HM049) |
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| 摘 要： | 目的探讨氟伏沙明对癌症后抑郁患者的临床疗效及对血清褪黑素的影响。方法选择癌症后抑郁患者100例为研究对象,按随机数字法分为2组,每组50例。对照组给予常规抗癌症治疗,观察组在对照组的基础上给予口服氟伏沙明治疗,连续治疗4周。于治疗前,治疗后1周、2周、4周采用汉密尔顿抑郁量表(HAMD)评定抑郁情况,采用汉密尔顿焦虑量表(HAMA)评定焦虑情况,采用日常生活能力量表(ADL)进行日常生活能力评估,采用反射免疫分析法测定治疗前、治疗后4周患者血清褪黑素水平。结果治疗后,观察组HAMD、HAMA为逐步降低(P<0.05);4周时HAMD、HAMA分别为(14.15±2.62)、(12.07±2.52),明显低于对照组的(22.53±3.18)、(21.58±4.06),P<0.05。治疗后,观察组ADL逐步升高(P<0.05);4周时ADL为(78.53±12.76)明显高于对照组的(61.03±12.08),P<0.05。治疗后,两组血清褪黑素水平均明显升高(P<0.05),观察组褪黑素水平为(52.89±7.35)ng/L,显著高于对照组的(40.46±3.76)ng/L,P<0.05。结论氟伏沙明治疗癌症后抑郁疗效显著,可明显改善患者抑郁症状,其作用机制可能与氟伏沙明可调节患者血清褪黑素水平有关。
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| 关 键 词： | 肿瘤 抑郁 褪黑激素 氟伏沙明 |
| 收稿时间： | 2017-09-23 |
Effects of fluphenazine on serum melatonin of patients with post-cancer depression |
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| Yang Qing,Yang Shaofeng,Zhang Lulu,Bi Xiaowei,Zhang Yan,Wang Mei and Shi Fenglei. Effects of fluphenazine on serum melatonin of patients with post-cancer depression[J]. Chinese Journal of Clinical Healthcare, 2017, 20(6): 676-678 |
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| Authors: | Yang Qing Yang Shaofeng Zhang Lulu Bi Xiaowei Zhang Yan Wang Mei Shi Fenglei |
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| Affiliation: | Pharmacy Department of Qingdao Municipal Hospital,Qingdao 266011,China,Pharmacy Department of Qingdao Municipal Hospital,Qingdao 266011,China,Pharmacy Department of Qingdao Municipal Hospital,Qingdao 266011,China,Pharmacy Department of Qingdao Municipal Hospital,Qingdao 266011,China,Pharmacy Department of Qingdao Municipal Hospital,Qingdao 266011,China,Pharmacy Department of Qingdao Municipal Hospital,Qingdao 266011,China and Pharmacy Department of Qingdao Municipal Hospital,Qingdao 266011,China |
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| Abstract: | Objective To investigate the effects of fluvoxamine on the depression and serum melatonin of patients with post-cancer.Methods 100 patients with post-cancer depression were selected as the study subjects and randomly divided into two groups.The control group was given routine anti-cancer treatment and the observation group was given oral administration of fluorophoramine based on the control group.All patients were treated for 4 weeks.After treatment of 1 week,2 weeks and 4 weeks,the depression was assessed by Hamilton Depression Scale (HAMD) and the anxiety was assessed using the Hamilton Anxiety Scale (HAMA).The living daily ability was assessed by living daily ability scale (ADL) and serum melatonin was detected by reflective immunoassay.Results After treatment,the HAMD and HAMA score of observation group were significantly reduced (P<0.05).HAMD and HAMA score of observation group at 4 week were significantly lower than those of control group[(14.15±2.62) VS.(22.53±3.18),(12.07±2.52) VS.(21.58±4.06),P<0.05).After treatment,the ADL score of observation group significantly increased gradually (P<0.05),ADL score of observation group at 4 week was significantly higher than that of control group [(78.53±12.76) VS.(61.03±12.08),P<0.05].After treatment,serum melatonin levels of two groups were both significantly increased (P<0.05),and the observation group was significantly higher than the control group [(52.89±7.35)ng/L VS.(40.46±3.76)ng/L,P<0.05].Conclusion Fluvoxamine could effectively treat post-cancer depression,improve the depressive symptoms.The mechanism may be related to its regulation of serum melatonin. |
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